(Histone-H3)-lysine-36 demethylase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = (Histone-H3)-lysine-36 demethylase

| EC_number = 1.14.11.27

| CAS_number =

| GO_code =

| image =

| width =

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}}

(Histone-H3)-lysine-36 demethylase ({{EC number|1.14.11.27}}, JHDM1A, JmjC domain-containing histone demethylase 1A, H3-K36-specific demethylase, histone-lysine (H3-K36) demethylase, histone demethylase, protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase) is an enzyme with systematic name protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase.{{cite journal | vauthors = Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y | title = Histone demethylation by a family of JmjC domain-containing proteins | journal = Nature | volume = 439 | issue = 7078 | pages = 811–6 | date = February 2006 | pmid = 16362057 | doi = 10.1038/nature04433 | bibcode = 2006Natur.439..811T }} This enzyme catalyses the following chemical reaction

: protein N6,N6-dimethyl-L-lysine + 2 2-oxoglutarate + 2 O₂ $\backslash rightleftharpoons$ protein L-lysine + 2 succinate + 2 formaldehyde + 2 CO₂ (overall reaction)

:(1a) protein N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O₂ $\backslash rightleftharpoons$ protein N6-methyl-L-lysine + succinate + formaldehyde + CO₂

:(1b) protein N6-methyl-L-lysine + 2-oxoglutarate + O2 $\backslash rightleftharpoons$ protein L-lysine + succinate + formaldehyde + CO₂

(Histone-H3)-lysine-36 demethylase contains iron(II).