(Phosphatase 2A protein)-leucine-carboxy methyltransferase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = (phosphatase 2A protein)-leucine-carboxy methyltransferase

| EC_number = 2.1.1.233

| CAS_number =

| GO_code =

| image =

| width =

| caption =

}}

(phosphatase 2A protein)-leucine-carboxy methyltransferase ({{EC number|2.1.1.233}}, leucine carboxy methyltransferase-1, LCMT1) is an enzyme with systematic name S-adenosyl-L-methionine:(phosphatase 2A protein)-leucine O-methyltransferase.{{cite journal | vauthors = De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J | title = Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue | journal = Biochemistry | volume = 38 | issue = 50 | pages = 16539–47 | date = December 1999 | pmid = 10600115 | doi = 10.1021/bi991646a }}{{cite journal | vauthors = Tsai ML, Cronin N, Djordjevic S | title = The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A | journal = Acta Crystallographica Section D | volume = 67 | issue = Pt 1 | pages = 14–24 | date = January 2011 | pmid = 21206058 | doi = 10.1107/s0907444910042204 }} This enzyme catalyses the following chemical reaction

: S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine $\backslash rightleftharpoons$ S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester

Methylates the C-terminal leucine of phosphatase 2A.