:(+)-cis-2-Aminomethylcyclopropane carboxylic acid
{{Distinguish|Cyclic adenosine monophosphate}}
{{DISPLAYTITLE:(+)-cis-2-Aminomethylcyclopropane carboxylic acid}}
{{Chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 477200460
| Name = (+)-cis-2-Aminomethylcyclopropane carboxylic acid
| ImageFile = (+)-CAMP.svg
| ImageFile_Ref = {{chemboximage|correct|??}}
| ImageName = Stereo, skeletal formula of (+)-cis-2-aminomethylcyclopropane carboxylic acid
| ImageFile1 = (+)-CAMP-3D-balls.png
| ImageName1 = C=black, H=white, O=red, N=blue
| ImageAlt1 = (+)-CAMP molecule
| PIN = (1S,2R)-2-(Aminomethyl)cyclopropane-1-carboxylic acid{{Cite web|title=AC1LT400 - Compound Summary|url=https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1502041|work=PubChem Compound|publisher=National Center for Biotechnology Information|access-date=7 October 2011|location=USA|date=11 July 2005|at=Identification and Related Records}}
|Section1={{Chembox Identifiers
| CASNo = 36489-13-1
| CASNo_Ref = {{cascite|changed|??}}
| PubChem = 1502041
| ChemSpiderID = 1236854
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChEMBL = 230115
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| SMILES = NC[C@@H]1C[C@@H]1C(O)=O
| StdInChI = 1S/C5H9NO2/c6-2-3-1-4(3)5(7)8/h3-4H,1-2,6H2,(H,7,8)/t3-,4-/m0/s1
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = QUFMERRXRMSAPZ-IMJSIDKUSA-N
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
}}
|Section2={{Chembox Properties
| C=5 | H=9 | N=1 | O=2
| Density = 1.275 g/mL
| BoilingPtC = 256.9
| LogP = −0.721
| pKa = 4.157
| pKb = 9.840
| IsoelectricPt = 7.01
}}
|Section3={{Chembox Related
| OtherFunction = ACPD
| OtherFunction_label = cycloalkanes
}}
}}
(+)-cis-2-Aminomethylcyclopropane carboxylic acid ((+)-CAMP) is an agonist for the GABAA-rho receptor.{{cite journal | last1 = Duke | first1 = RK | last2 = Chebib | first2 = M | last3 = Balcar | first3 = VJ | last4 = Allan | first4 = RD | last5 = Mewett | first5 = KN | last6 = Johnston | first6 = GA | title = (+)- and (−)-cis-2-aminomethylcyclopropanecarboxylic acids show opposite pharmacology at recombinant rho(1) and rho(2) GABA(C) receptors | journal = Journal of Neurochemistry | volume = 75 | issue = 6 | pages = 2602–10 | year = 2000 | pmid = 11080214 | doi=10.1046/j.1471-4159.2000.0752602.x| doi-access = free }}{{cite journal | last1 = Carland | first1 = JE | last2 = Moorhouse | first2 = AJ | last3 = Barry | first3 = PH | last4 = Johnston | first4 = GA | last5 = Chebib | first5 = M | title = Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability | journal = The Journal of Biological Chemistry | volume = 279 | issue = 52 | pages = 54153–60 | year = 2004 | pmid = 15485818 | doi = 10.1074/jbc.M410625200 | doi-access = free }}
References
{{Reflist|2}}
{{GABAergics}}
{{DEFAULTSORT:aminomethylcyclopropane carboxylic acid}}
Category:GABAA-rho receptor agonists
{{Amine-stub}}
{{Nervous-system-drug-stub}}