:(+)-epicubenol synthase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = (+)-epicubenol synthase

| EC_number = 4.2.3.64

| CAS_number =

| GO_code =

| image =

| width =

| caption =

}}

(+)-Epicubenol synthase (EC 4.2.3.64, farnesyl pyrophosphate cyclase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((+)-epicubenol-forming).{{cite journal | vauthors = Cane DE, Tandon M, Prabhakaran PC | title = Epicubenol synthase and the enzymatic cyclization of farnesyl diphosphate |journal = J. Am. Chem. Soc. |year = 1993 |volume = 115 | issue = 18 |pages = 8103–8106 |doi=10.1021/ja00071a023}}{{cite journal | vauthors = Cane DE, Tandon M | title = Biosynthesis of (+)-epicubenol. |journal = Tetrahedron Lett. |year = 1994 |volume = 35 | issue = 30 |pages = 5355–5358 |doi=10.1016/s0040-4039(00)73498-8}}{{cite journal | vauthors = Cane DE, Tandon M | title = Epicubenol synthase and the stereochemistry of the enzymatic cyclization of farnesyl and nerolidyl diphosphate |journal = J. Am. Chem. Soc. |year = 1995 |volume = 117 | issue = 20 |pages = 5602–5603 |doi=10.1021/ja00125a029}}{{cite journal | vauthors = Nabeta K, Kigure K, Fujita M, Nagoya T, Ishikawa T, Okuyama H, Takasawa T | title = Bioynthesis of (+)-cubenene and (+)-epicubenol by cell-free extracts of cultured cells of Heteroscyphus planus and cyclization of [²H]farnesyl diphosphates | journal = J. Chem. Soc., Perkin Trans. 1 |year = 1995 | issue = 15 |pages = 1935–1939 |doi=10.1039/p19950001935}}{{cite journal | vauthors = Nabeta K, Fujita M, Komuro K, Katayama K, Takasawa T | title = In vitro biosynthesis of cadinanes by cell-free extracts of cultured cells of Heteroscyphus planus |journal = J. Chem. Soc., Perkin Trans. 1 |year = 1997 | issue = 14 |pages = 2065–2070 |doi=10.1039/a701145h}} This enzyme catalyses the following chemical reaction

: (2E,6E)-farnesyl diphosphate + H₂O $\backslash rightleftharpoons$ (+)-epicubenol + diphosphate

This enzyme requires Mg²⁺.