:(6-4)DNA photolyase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = (6-4)DNA photolyase

| EC_number = 4.1.99.13

| CAS_number = 37290-70-3

| GO_code =

| image =

| width =

| caption =

}}

(6-4)DNA photolyase ({{EnzExplorer|4.1.99.13}}, DNA photolyase, H64PRH, NF-10, phr (6-4), PL-(6-4), OtCPF1, (6-4) PHR, At64PHR) is an enzyme with systematic name (6-4) photoproduct pyrimidine-lyase.{{cite journal | vauthors = Hitomi K, DiTacchio L, Arvai AS, Yamamoto J, Kim ST, Todo T, Tainer JA, Iwai S, Panda S, Getzoff ED|authorlink10=Elizabeth D. Getzoff | title = Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 106 | issue = 17 | pages = 6962–7 | date = April 2009 | pmid = 19359474 | pmc = 2678464 | doi = 10.1073/pnas.0809180106 |bibcode=2009PNAS..106.6962H |doi-access=free }}{{cite journal | vauthors = Schleicher E, Hitomi K, Kay CW, Getzoff ED, Todo T, Weber S | title = Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase | journal = The Journal of Biological Chemistry | volume = 282 | issue = 7 | pages = 4738–47 | date = February 2007 | pmid = 17164245 | doi = 10.1074/jbc.m604734200 | doi-access = free }} This enzyme catalyses the following chemical reaction

: (6-4) photoproduct (in DNA) $\backslash rightleftharpoons$ 2 pyrimidine residues (in DNA)

This enzyme is a flavoprotein.