:1,3-Difluoro-2-propanol

{{chembox

| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 477205240

| ImageFile =1,3-Difluoro-2-propanol-2D-by-AHRLS-2012.png

| ImageSize = 120px

| ImageFileL2 = 1,3-Difluoro-2-propanol-3D-balls-by-AHRLS-2012.png

| ImageSizeL2 = 120px

| ImageFileR2 = 1,3-Difluoro-2-propanol-3D-vdW-by-AHRLS-2012.png

| ImageSizeR2 = 120px

| PIN =1,3-Difluoropropan-2-ol

| OtherNames =

|Section1={{Chembox Identifiers

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 61300

| InChI = 1/C3H6F2O/c4-1-3(6)2-5/h3,6H,1-2H2

| SMILES1 = FCC(O)CF

| InChIKey = PVDLUGWWIOGCNH-UHFFFAOYAJ

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChI = 1S/C3H6F2O/c4-1-3(6)2-5/h3,6H,1-2H2

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey = PVDLUGWWIOGCNH-UHFFFAOYSA-N

| CASNo_Ref = {{cascite|changed|??}}

| CASNo =453-13-4

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = R8ZM2LQG7K

| PubChem =67985

| SMILES =OC(CF)CF

}}

|Section2={{Chembox Properties

| C=3 | H=6 | F=2 | O=1

| Appearance =

| Density =1.24 g/cm3 (at 25 °C) [http://www.sigmaaldrich.com/catalog/product/aldrich/176923?lang=en®ion=US Sigma Aldrich]

| MeltingPt =

| BoilingPtC = 54 to 55

| BoilingPt_notes =

| Solubility =

}}

|Section3={{Chembox Hazards

| MainHazards =

| FlashPtC =42

| AutoignitionPtC =

}}

}}

1,3-Difluoro-2-propanol is a metabolic poison which disrupts the citric acid cycle and is used as a rodenticide, similar to sodium fluoroacetate. It is the main ingredient (along with 1-chloro-3-fluoro-2-propanol) in the rodenticide product Gliftor which was widely used in the former USSR{{cite journal | vauthors = Buklan AI, Kravets AF | title = [Gliftor poisoning] | language = ru | journal = Sudebno-Meditsinskaia Ekspertiza | volume = 29 | issue = 1 | pages = 55–6 | year = 1986 | pmid = 3961873 }}{{cite journal | vauthors = Feldwick MG, Noakes PS, Prause U, Mead RJ, Kostyniak PJ | title = The biochemical toxicology of 1,3-difluoro-2-propanol, the major ingredient of the pesticide gliftor: the potential of 4-methylpyrazole as an antidote | journal = Journal of Biochemical and Molecular Toxicology | volume = 12 | issue = 1 | pages = 41–52 | year = 1998 | pmid = 9414486 | doi = 10.1002/(SICI)1099-0461(1998)12:1<41::AID-JBT6>3.0.CO;2-P | s2cid = 29455648 }}{{cite journal | vauthors = Menon KI, Feldwick MG, Noakes PS, Mead RJ | title = The mode of toxic action of the pesticide gliftor: the metabolism of 1,3-difluoroacetone to (−)-erythro-fluorocitrate | journal = Journal of Biochemical and Molecular Toxicology | volume = 15 | issue = 1 | pages = 47–54 | year = 2001 | pmid = 11170315 | doi = 10.1002/1099-0461(2001)15:1<47::AID-JBT6>3.0.CO;2-E | s2cid = 9064673 }} and still approved in China.{{cite web |last1=Wood |first1=Alan |title=Gliftor |url=http://www.alanwood.net/pesticides/gliftor.html |website=Compendium of Pesticide Common Names |access-date=14 June 2021}}

References

{{reflist}}

{{rodenticides}}

{{DEFAULTSORT:Difluoro-2-propanol, 1,3-}}

Category:Rodenticides

Category:Fluorohydrins

Category:Respiratory toxins