:16S rRNA (adenine1408-N1)-methyltransferase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = 16S rRNA (adenine¹⁴⁰⁸-N¹)-methyltransferase

| EC_number = 2.1.1.180

| CAS_number =

| GO_code =

| image =

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| caption =

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16S rRNA (adenine¹⁴⁰⁸-N¹)-methyltransferase ({{EC number|2.1.1.180}}, kanamycin-apramycin resistance methylase, 16S rRNA:m1A1408 methyltransferase, KamB, NpmA, 16S rRNA m1A1408 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (adenine¹⁴⁰⁸-N¹)-methyltransferase.{{cite journal | vauthors = Beauclerk AA, Cundliffe E | title = Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides | journal = Journal of Molecular Biology | volume = 193 | issue = 4 | pages = 661–71 | date = February 1987 | pmid = 2441068 | doi = 10.1016/0022-2836(87)90349-4 }}{{cite journal | vauthors = Koscinski L, Feder M, Bujnicki JM | title = Identification of a missing sequence and functionally important residues of 16S rRNA:m(1)A1408 methyltransferase KamB that causes bacterial resistance to aminoglycoside antibiotics | journal = Cell Cycle | volume = 6 | issue = 10 | pages = 1268–71 | date = May 2007 | pmid = 17495534 | doi = 10.4161/cc.6.10.4231 | doi-access = free }}{{cite journal | vauthors = Holmes DJ, Drocourt D, Tiraby G, Cundliffe E | title = Cloning of an aminoglycoside-resistance-encoding gene, kamC, from Saccharopolyspora hirsuta: comparison with kamB from Streptomyces tenebrarius | journal = Gene | volume = 102 | issue = 1 | pages = 19–26 | date = June 1991 | pmid = 1840536 | doi = 10.1016/0378-1119(91)90532-g }}{{cite journal | vauthors = Wachino J, Shibayama K, Kurokawa H, Kimura K, Yamane K, Suzuki S, Shibata N, Ike Y, Arakawa Y | title = Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides | journal = Antimicrobial Agents and Chemotherapy | volume = 51 | issue = 12 | pages = 4401–9 | date = December 2007 | pmid = 17875999 | pmc = 2168023 | doi = 10.1128/aac.00926-07 }} This enzyme catalyses the following chemical reaction

: S-adenosyl-L-methionine + adenine¹⁴⁰⁸ in 16S rRNA $\backslash rightleftharpoons$ S-adenosyl-L-homocysteine + N¹-methyladenine¹⁴⁰⁸ in 16S rRNA

The enzyme provides a {{Not a typo|panaminoglycoside}} resistance through interference with the binding of aminoglycosides.