:2,7,4'-Trihydroxyisoflavanone 4'-O-methyltransferase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = 2,7,4'-Trihydroxyisoflavanone 4'-O-methyltransferase

| EC_number = 2.1.1.212

| CAS_number =

| GO_code =

| image =

| width =

| caption =

}}

2,7,4'-Trihydroxyisoflavanone 4'-O-methyltransferase ({{EC number|2.1.1.212}}, SAM:2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase, HI4'OMT, HMM1, MtIOMT5) is an enzyme with systematic name S-adenosyl-L-methionine:2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase .{{cite journal | vauthors = Akashi T, Sawada Y, Shimada N, Sakurai N, Aoki T, Ayabe S | title = cDNA cloning and biochemical characterization of S-adenosyl-L-methionine: 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase, a critical enzyme of the legume isoflavonoid phytoalexin pathway | journal = Plant & Cell Physiology | volume = 44 | issue = 2 | pages = 103–12 | date = February 2003 | pmid = 12610212 | doi = 10.1093/pcp/pcg034 | doi-access = free }}{{cite journal | vauthors = Deavours BE, Liu CJ, Naoumkina MA, Tang Y, Farag MA, Sumner LW, Noel JP, Dixon RA | title = Functional analysis of members of the isoflavone and isoflavanone O-methyltransferase enzyme families from the model legume Medicago truncatula | journal = Plant Molecular Biology | volume = 62 | issue = 4-5 | pages = 715–33 | date = November 2006 | pmid = 17001495 | pmc = 2862459 | doi = 10.1007/s11103-006-9050-x }}{{cite journal | vauthors = Liu CJ, Deavours BE, Richard SB, Ferrer JL, Blount JW, Huhman D, Dixon RA, Noel JP | title = Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses | journal = The Plant Cell | volume = 18 | issue = 12 | pages = 3656–69 | date = December 2006 | pmid = 17172354 | pmc = 1785397 | doi = 10.1105/tpc.106.041376 }}{{cite journal | vauthors = Akashi T, VanEtten HD, Sawada Y, Wasmann CC, Uchiyama H, Ayabe S | title = Catalytic specificity of pea O-methyltransferases suggests gene duplication for (+)-pisatin biosynthesis | journal = Phytochemistry | volume = 67 | issue = 23 | pages = 2525–30 | date = December 2006 | doi = 10.1016/j.phytochem.2006.09.010 }} This enzyme catalyses the following chemical reaction

: S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone $\backslash rightleftharpoons$ S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone

This enzyme specifically methylates 2,7,4'-trihydroxyisoflavanone on the 4'-position.