:2-Amino-4-deoxychorismate synthase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = 2-amino-4-deoxychorismate synthase

| EC_number = 2.6.1.86

| CAS_number =

| GO_code =

| image =

| width =

| caption =

}}

2-amino-4-deoxychorismate synthase ({{EC number|2.6.1.86}}, ADIC synthase, 2-amino-2-deoxyisochorismate synthase, SgcD) is an enzyme with systematic name (2S)-2-amino-4-deoxychorismate:2-oxoglutarate aminotransferase.{{cite journal | vauthors = Van Lanen SG, Lin S, Shen B | title = Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 105 | issue = 2 | pages = 494–9 | date = January 2008 | pmid = 18182490 | pmc = 2206564 | doi = 10.1073/pnas.0708750105 | bibcode = 2008PNAS..105..494V | doi-access = free }}{{cite journal | title = The benzoxazolinate of C-1027 confers intercalative DNA binding |author1 = Yu, L. |author2 =Mah, S. |author3 =Otani, T. |author4 =Dedon, P. |journal = J. Am. Chem. Soc. |year = 1995 |volume = 117 |issue = 34 |pages = 8877–8878 |doi=10.1021/ja00139a032}}{{cite journal | vauthors = McDonald M, Mavrodi DV, Thomashow LS, Floss HG | title = Phenazine biosynthesis in Pseudomonas fluorescens: branchpoint from the primary shikimate biosynthetic pathway and role of phenazine-1,6-dicarboxylic acid | journal = Journal of the American Chemical Society | volume = 123 | issue = 38 | pages = 9459–60 | date = September 2001 | pmid = 11562236 | doi = 10.1021/ja011243 }}{{cite journal | vauthors = Laursen JB, Nielsen J | title = Phenazine natural products: biosynthesis, synthetic analogues, and biological activity | journal = Chemical Reviews | volume = 104 | issue = 3 | pages = 1663–86 | date = March 2004 | pmid = 15008629 | doi = 10.1021/cr020473j }} This enzyme catalyses the following chemical reaction

: (2S)-2-amino-4-deoxychorismate + L-glutamate $\backslash rightleftharpoons$ chorismate + L-glutamine

This enzyme requires Mg²⁺. The reaction occurs in the reverse direction.