:2-Hydroxymuconate semialdehyde

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| ImageFile = 2-hydroxymuconate semialdehyde ZE.svg

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| PIN = (2Z,4E)-2-Hydroxy-6-oxohexa-2,4-dienoic acid

| OtherNames = hydroxymuconic semialdehyde; 2-hydroxymuconate semialdehyde; 2-hydroxymuconate-6-semialdehyde

|Section1={{Chembox Identifiers

| CASNo = 3270-98-2

| PubChem = 5280366

| ChemSpiderID = 13294906

| SMILES = C(=C/C=O)\C=C(\C(=O)O)/O

| StdInChI = 1S/C6H6O4/c7-4-2-1-3-5(8)6(9)10/h1-4,8H,(H,9,10)/b2-1+,5-3-

| StdInChIKey = KGLCZTRXNNGESL-WFTYEQLWSA-N

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|Section2={{Chembox Properties

| C=6 | H=6 | O=4

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|Section3={{Chembox Hazards

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2-Hydroxymuconate semialdehyde is formed from catechol by the enzyme catechol 2,3-dioxygenase during the degradation of benzoates.{{cite journal | author = Sala-Trepat JM, Evans WC | date = 1971 | title = The meta cleavage of catechol by Azotobacter species 4-Oxalocrotonate pathway | journal = Eur. J. Biochem. | volume = 20 | pages = 400–13 | pmid = 4325686 | doi = 10.1111/j.1432-1033.1971.tb01406.x | issue = 3 | doi-access = free }} It is hydrolysed into formate and 2-oxopent-4-enoate by 2-hydroxymuconate-semialdehyde hydrolase.