:2-hydroxyethylphosphonate dioxygenase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = 2-hydroxyethylphosphonate dioxygenase

| EC_number = 1.13.11.72

| CAS_number =

| GO_code =

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2-hydroxyethylphosphonate dioxygenase ({{EC number|1.13.11.72}}, HEPD, phpD (gene)) is an enzyme with systematic name 2-hydroxyethylphosphonate:O₂ 1,2-oxidoreductase (hydroxymethylphosphonate forming).{{cite journal | vauthors = Cicchillo RM, Zhang H, Blodgett JA, Whitteck JT, Li G, Nair SK, van der Donk WA, Metcalf WW | title = An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis | journal = Nature | volume = 459 | issue = 7248 | pages = 871–4 | date = June 2009 | pmid = 19516340 | pmc = 2874955 | doi = 10.1038/nature07972 }}{{cite journal | vauthors = Whitteck JT, Malova P, Peck SC, Cicchillo RM, Hammerschmidt F, van der Donk WA | title = On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase | journal = Journal of the American Chemical Society | volume = 133 | issue = 12 | pages = 4236–9 | date = March 2011 | pmid = 21381767 | pmc = 3069692 | doi = 10.1021/ja1113326 }}{{cite journal | vauthors = Peck SC, Cooke HA, Cicchillo RM, Malova P, Hammerschmidt F, Nair SK, van der Donk WA | title = Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase | journal = Biochemistry | volume = 50 | issue = 30 | pages = 6598–605 | date = August 2011 | pmid = 21711001 | pmc = 3143709 | doi = 10.1021/bi200804r }} This enzyme catalyses the following chemical reaction

: 2-hydroxyethylphosphonate + O₂ $\backslash rightleftharpoons$ hydroxymethylphosphonate + formate

2-hydroxyethylphosphonate dioxygenase contains non-heme-Fe(II).