:2-oxoglutaramate amidase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = 2-oxoglutaramate amidase

| EC_number = 3.5.1.111

| CAS_number =

| GO_code =

| image =

| width =

| caption =

}}

2-oxoglutaramate amidase ({{EC number|3.5.1.111}}, omega-amidase) is an enzyme with systematic name 5-amino-2,5-dioxopentanoate amidohydrolase.{{cite journal | vauthors = Cobzaru C, Ganas P, Mihasan M, Schleberger P, Brandsch R | title = Homologous gene clusters of nicotine catabolism, including a new ω-amidase for α-ketoglutaramate, in species of three genera of Gram-positive bacteria | journal = Research in Microbiology | volume = 162 | issue = 3 | pages = 285–91 | date = April 2011 | pmid = 21288482 | doi = 10.1016/j.resmic.2011.01.001 }} This enzyme catalyses the following chemical reaction

: 2-oxoglutaramate + H₂O $\backslash rightleftharpoons$ 2-oxoglutarate + ammonia

The enzyme participates in the nicotine degradation pathway of several Gram-positive bacteria.