:23S rRNA (guanine2445-N2)-methyltransferase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = 23S rRNA (guanine²⁴⁴⁵-N²)-methyltransferase

| EC_number = 2.1.1.173

| CAS_number =

| GO_code =

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}}

23S rRNA (guanine²⁴⁴⁵-N²)-methyltransferase ({{EC number|2.1.1.173}}, ycbY (gene), rlmL (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine²⁴⁴⁵-N²)-methyltransferase.{{cite journal | vauthors = Lesnyak DV, Sergiev PV, Bogdanov AA, Dontsova OA | title = Identification of Escherichia coli m2G methyltransferases: I. the ycbY gene encodes a methyltransferase specific for G2445 of the 23 S rRNA | journal = Journal of Molecular Biology | volume = 364 | issue = 1 | pages = 20–5 | date = November 2006 | pmid = 17010378 | doi = 10.1016/j.jmb.2006.09.009 }} This enzyme catalyses the following chemical reaction

: S-adenosyl-L-methionine + guanine²⁴⁴⁵ in 23S rRNA $\backslash rightleftharpoons$ S-adenosyl-L-homocysteine + N²-methylguanine²⁴⁴⁵ in 23S rRNA

The enzyme methylates 23S rRNA in vitro.