:23S rRNA (uridine2479-2'-O)-methyltransferase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = 23S rRNA (uridine²⁴⁷⁹-2'-O)-methyltransferase

| EC_number = 2.1.1.208

| CAS_number =

| GO_code =

| image =

| width =

| caption =

}}

23S rRNA (uridine²⁴⁷⁹-2'-O)-methyltransferase ({{EC number|2.1.1.208}}, AviRb) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (uridine²⁴⁷⁹-2'-O)-methyltransferase.{{cite journal | vauthors = Mosbacher TG, Bechthold A, Schulz GE | title = Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes | journal = Journal of Molecular Biology | volume = 345 | issue = 3 | pages = 535–45 | date = January 2005 | pmid = 15581897 | doi = 10.1016/j.jmb.2004.10.051 }}{{cite journal | vauthors = Treede I, Jakobsen L, Kirpekar F, Vester B, Weitnauer G, Bechthold A, Douthwaite S | title = The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose | journal = Molecular Microbiology | volume = 49 | issue = 2 | pages = 309–18 | date = July 2003 | pmid = 12828631 | doi = 10.1046/j.1365-2958.2003.03558.x | doi-access = free }}{{cite journal | vauthors = Weitnauer G, Gaisser S, Trefzer A, Stockert S, Westrich L, Quiros LM, Mendez C, Salas JA, Bechthold A | title = An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tü57 | journal = Antimicrobial Agents and Chemotherapy | volume = 45 | issue = 3 | pages = 690–5 | date = March 2001 | pmid = 11181344 | pmc = 90357 | doi = 10.1128/aac.45.3.690-695.2001 }} This enzyme catalyses the following chemical reaction

: S-adenosyl-L-methionine + uridine²⁴⁷⁹ in 23S rRNA $\backslash rightleftharpoons$ S-adenosyl-L-homocysteine + 2'-O-methyluridine²⁴⁷⁹ in 23S rRNA

Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis.{{cite journal | vauthors = Krupkin M, Wekselman I, Matzov D, Eyal Z, Diskin Posner Y, Rozenberg H, Zimmerman E, Bashan A, Yonath A | title = Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 113 | issue = 44 | pages = E6796–E6805 | date = November 2016 | pmid = 27791159 | pmc = 5098648 | doi = 10.1073/pnas.1614297113 | doi-access = free }}