:6-Hydroxynicotinate 3-monooxygenase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = 6-Hydroxynicotinate 3-monooxygenase

| EC_number = 1.14.13.114

| CAS_number =

| GO_code =

| image =

| width =

| caption =

}}

6-Hydroxynicotinate 3-monooxygenase ({{EC number|1.14.13.114}}, NicC, 6HNA monooxygenase, HNA-3-monooxygenase) is an enzyme with systematic name 6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating).{{cite journal | vauthors = Nakano H, Wieser M, Hurh B, Kawai T, Yoshida T, Yamane T, Nagasawa T | title = Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5 | journal = European Journal of Biochemistry | volume = 260 | issue = 1 | pages = 120–6 | date = February 1999 | pmid = 10091591 | doi = 10.1046/j.1432-1327.1999.00124.x | doi-access = free }}{{cite journal | vauthors = Jiménez JI, Canales A, Jiménez-Barbero J, Ginalski K, Rychlewski L, García JL, Díaz E | title = Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 105 | issue = 32 | pages = 11329–34 | date = August 2008 | pmid = 18678916 | pmc = 2516282 | doi = 10.1073/pnas.0802273105 | bibcode = 2008PNAS..10511329J | doi-access = free }} This enzyme catalyses the following chemical reaction

: 6-hydroxynicotinate + NADH + H⁺ + O₂ $\backslash rightleftharpoons$ 2,5-dihydroxypyridine + NAD⁺ + H₂O + CO₂

6-Hydroxynicotinate 3-monooxygenase a flavoprotein (FAD).