:8-oxo-dGTP diphosphatase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = 8-oxo-dGTP diphosphatase

| EC_number = 3.6.1.55

| CAS_number =

| GO_code =

| image =

| width =

| caption =

}}

8-oxo-dGTP diphosphatase ({{EC number|3.6.1.55}}, MutT, 7,8-dihydro-8-oxoguanine triphosphatase, 8-oxo-dGTPase, 7,8-dihydro-8-oxo-dGTP pyrophosphohydrolase) is an enzyme with systematic name 8-oxo-dGTP diphosphohydrolase.{{cite journal | vauthors = Ito R, Hayakawa H, Sekiguchi M, Ishibashi T | title = Multiple enzyme activities of Escherichia coli MutT protein for sanitization of DNA and RNA precursor pools | journal = Biochemistry | volume = 44 | issue = 17 | pages = 6670–4 | date = May 2005 | pmid = 15850400 | doi = 10.1021/bi047550k }}{{cite journal | vauthors = Yoshimura K, Ogawa T, Ueda Y, Shigeoka S | title = AtNUDX1, an 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase, is responsible for eliminating oxidized nucleotides in Arabidopsis | journal = Plant & Cell Physiology | volume = 48 | issue = 10 | pages = 1438–49 | date = October 2007 | pmid = 17804481 | doi = 10.1093/pcp/pcm112 | doi-access = free }}{{cite journal | vauthors = Nakamura T, Meshitsuka S, Kitagawa S, Abe N, Yamada J, Ishino T, Nakano H, Tsuzuki T, Doi T, Kobayashi Y, Fujii S, Sekiguchi M, Yamagata Y | title = Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base | journal = The Journal of Biological Chemistry | volume = 285 | issue = 1 | pages = 444–52 | date = January 2010 | pmid = 19864691 | pmc = 2804192 | doi = 10.1074/jbc.m109.066373 | doi-access = free }}{{cite journal | vauthors = Yonekura S, Sanada U, Zhang-Akiyama QM | title = CiMutT, an asidian MutT homologue, has a 7, 8-dihydro-8-oxo-dGTP pyrophosphohydrolase activity responsible for sanitization of oxidized nucleotides in Ciona intestinalis | journal = Genes & Genetic Systems | volume = 85 | issue = 4 | pages = 287–95 | year = 2010 | pmid = 21178309 | doi = 10.1266/ggs.85.287 | doi-access = free }} This enzyme catalyses the following chemical reaction:

: 8-oxo-dGTP + H₂O $\backslash rightleftharpoons$ 8-oxo-dGMP + diphosphate

This enzyme requires Mg²⁺.