:Agosterol A

{{Chembox

| ImageFile = Agosterol_A.svg

| ImageSize = 200px

| ImageAlt =

| IUPACName = (22R)-11α,22-Dihydroxy-5α-cholest-7-ene-3β,4β,6α-triyl triacetate

| SystematicName = (1R,3aR,5S,5aS,6R,7S,9aR,9bR,10R,11aR)-10-Hydroxy-1-[(2S,3R)-3-hydroxy-6-methylheptan-2-yl]-9a,11a-dimethyl-2,3,3a,5,5a,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthrene-5,6,7-triyl triacetate

| OtherNames =

|Section1={{Chembox Identifiers

| CASNo = 213549-32-7

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = YTC6258TAR

| PubChem = 10348156

| ChemSpiderID = 8523614

| SMILES = C[C@@H]([C@H]1CC[C@@H]2[C@@]1(C[C@H]([C@H]3C2=C[C@@H]([C@@H]4[C@@]3(CC[C@@H]([C@@H]4OC(=O)C)OC(=O)C)C)OC(=O)C)O)C)[C@@H](CCC(C)C)O

| InChI = 1/C33H52O8/c1-17(2)9-12-25(37)18(3)23-10-11-24-22-15-28(40-20(5)35)30-31(41-21(6)36)27(39-19(4)34)13-14-32(30,7)29(22)26(38)16-33(23,24)8/h15,17-18,23-31,37-38H,9-14,16H2,1-8H3/t18-,23+,24-,25+,26+,27-,28-,29+,30-,31-,32+,33+/m0/s1

| InChIKey = SUIRSZOPEPPNGJ-JGEDILIOBG

| StdInChI = 1S/C33H52O8/c1-17(2)9-12-25(37)18(3)23-10-11-24-22-15-28(40-20(5)35)30-31(41-21(6)36)27(39-19(4)34)13-14-32(30,7)29(22)26(38)16-33(23,24)8/h15,17-18,23-31,37-38H,9-14,16H2,1-8H3/t18-,23+,24-,25+,26+,27-,28-,29+,30-,31-,32+,33+/m0/s1

| StdInChIKey = SUIRSZOPEPPNGJ-JGEDILIOSA-N }}

|Section2={{Chembox Properties

| C=33

| H=52

| O=8

| Appearance =

| Density =

| MeltingPt =

| BoilingPt =

| Solubility = }}

|Section3={{Chembox Hazards

| MainHazards =

| FlashPt =

| AutoignitionPt = }}

}}

Agosterol A is a bio-active sterol which may have applications in removing multi-drug resistance in various cancers.{{cite journal|last1=Chen|first1=Zhe-Sheng|last2=Aoki|first2=Shunji|last3=Komatsu|first3=Masaharu|last4=Ueda|first4=Kazumitsu|last5=Sumizawa|first5=Tomoyuki|last6=Furukawa|first6=Tatsuhiko|last7=Okumura|first7=Hiroshi|last8=Ren|first8=Xiao-Qin|last9=Belinsky|first9=Martin G.|last10=Lee|first10=Kun|last11=Kruh|first11=Gary D.|last12=Kobayashi|first12=Motomasa|last13=Akiyama|first13=Shin-ichi|title=Reversal of drug resistance mediated by multidrug resistance protein (MRP) 1 by dual effects of agosterol a on MRP1 function|journal=International Journal of Cancer|volume=93|issue=1|year=2001|pages=107–113|issn=0020-7136|doi=10.1002/ijc.1290|pmid=11391629 |doi-access=free}}{{cite journal|last1=Aoki|first1=Shunji|last2=Chen|first2=Zhe-Sheng|last3=Higasiyama|first3=Kimihiko|last4=Setiawan|first4=I|last5=Akiyama|first5=Shin-ichi|last6=Kobayashi|first6=Motomasa|title=Reversing Effect of Agosterol A, a Spongean Sterol Acetate, on Multidrug Resistance in Human Carcinoma Cells|journal=Japanese Journal of Cancer Research|volume=92|issue=8|year=2001|pages=886–895|issn=0910-5050|doi=10.1111/j.1349-7006.2001.tb01177.x|pmid=11509122 |pmc=5926837}} It was first isolated from marine sponge but has also been produced synthetically.{{cite journal|last1=Murakami|first1=Nobutoshi|last2=Sugimoto|first2=Masanori|last3=Morita|first3=Mari|last4=Kobayashi|first4=Motomasa|title=Total Synthesis of Agosterol A: an MDR-Modulator from a Marine Sponge|journal=Chemistry: A European Journal|volume=7|issue=12|year=2001|pages=2663–2670|issn=0947-6539|doi=10.1002/1521-3765(20010618)7:12<2663::AID-CHEM26630>3.0.CO;2-U|pmid=11465457 }}