:Alpha-isocomene synthase

{{Infobox enzyme

| Name = α-isocomene synthase

| EC_number = 4.2.3.136

| CAS_number =

| GO_code =

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α-Isocomene synthase (EC 4.2.3.136, MrTPS2) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (–)-α-isocomene-forming).{{cite journal | vauthors = Irmisch S, Krause ST, Kunert G, Gershenzon J, Degenhardt J, Köllner TG | title = The organ-specific expression of terpene synthase genes contributes to the terpene hydrocarbon composition of chamomile essential oils | journal = BMC Plant Biology | volume = 12 | pages = 84 | date = June 2012 | pmid = 22682202 | pmc = 3423072 | doi = 10.1186/1471-2229-12-84 | doi-access = free }} This enzyme catalyses the following chemical reaction

: (2E,6E)-farnesyl diphosphate $\backslash rightleftharpoons$ (–)-α-isocomene + diphosphate

This enzyme is isolated from the roots of the plant Matricaria chamomilla var. recutita (chamomile).