:Alpha-muurolene synthase

{{Infobox enzyme

| Name = α-muurolene synthase

| EC_number = 4.2.3.125

| CAS_number =

| GO_code =

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α-Muurolene synthase (EC 4.2.3.125, Cop3) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, α-muurolene-forming).{{cite journal | vauthors = Agger S, Lopez-Gallego F, Schmidt-Dannert C | title = Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus | journal = Molecular Microbiology | volume = 72 | issue = 5 | pages = 1181–95 | date = June 2009 | pmid = 19400802 | pmc = 2723806 | doi = 10.1111/j.1365-2958.2009.06717.x }}{{cite journal | vauthors = López-Gallego F, Wawrzyn GT, Schmidt-Dannert C | title = Selectivity of fungal sesquiterpene synthases: role of the active site's H-1α loop in catalysis | journal = Applied and Environmental Microbiology | volume = 76 | issue = 23 | pages = 7723–33 | date = December 2010 | pmid = 20889795 | pmc = 2988597 | doi = 10.1128/aem.01811-10 | bibcode = 2010ApEnM..76.7723L }} This enzyme catalyses the following chemical reaction

: (2E,6E)-farnesyl diphosphate $\backslash rightleftharpoons$ α-muurolene + diphosphate

The enzyme has been characterized from the fungus Coprinus cinereus.