:Arecaidine

{{Short description|Chemical compound}}

{{Infobox drug

| drug_name = Arecaidine

| image = Arecaidine.svg

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| CAS_number = 499-04-7

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| PubChem = 10355

| IUPHAR_ligand = 9487

| DrugBank =

| ChemSpiderID = 9928

| UNII = 0S8YEV0D4O

| KEGG = C10128

| ChEBI = 2813

| ChEMBL = 432561

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| synonyms = Methylguvacine; Arecaine; N-Methylguvacine

| IUPAC_name = 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid

| C = 7

| H = 11

| N = 1

| O = 2

| SMILES = CN1CCC=C(C1)C(=O)O

| StdInChI = 1S/C7H11NO2/c1-8-4-2-3-6(5-8)7(9)10/h3H,2,4-5H2,1H3,(H,9,10)

| StdInChIKey = DNJFTXKSFAMXQF-UHFFFAOYSA-N

}}

Arecaidine is a bio-active alkaloid in areca nuts.{{cite journal | vauthors = Voigt V, Laug L, Zebisch K, Thondorf I, Markwardt F, Brandsch M | title = Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1) | journal = The Journal of Pharmacy and Pharmacology | volume = 65 | issue = 4 | pages = 582–590 | date = April 2013 | pmid = 23488788 | doi = 10.1111/jphp.12006 | s2cid = 27577546 | doi-access = free }} It is a competitive GABA reuptake inhibitor.{{cite journal | vauthors = Johnston GA, Krogsgaard-Larsen P, Stephanson A | title = Betel nut constituents as inhibitors of gamma-aminobutyric acid uptake | journal = Nature | volume = 258 | issue = 5536 | pages = 627–628 | date = December 1975 | pmid = 1207742 | doi = 10.1038/258627a0 | s2cid = 4147760 | bibcode = 1975Natur.258..627J }} Lime is said to hydrolyse arecoline to arecaidine