:Cannabipiperidiethanone

{{Short description|Chemical compound}}

{{Drugbox

| IUPAC_name = 2-(2-Methoxyphenyl)-1-[1-([1-methylpiperidin-2-yl]methyl)indol-3-yl]ethanone

| image = Cannabipiperidiethanone_structure.png

| image_class = skin-invert-image

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| legal_US = Schedule I

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| CAS_number = 1345970-43-5

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = G66388U44D

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| ChemSpiderID = 27330303

| StdInChI = 1S/C24H28N2O2/c1-25-14-8-7-10-19(25)16-26-17-21(20-11-4-5-12-22(20)26)23(27)15-18-9-3-6-13-24(18)28-2/h3-6,9,11-13,17,19H,7-8,10,14-16H2,1-2H3

| StdInChIKey = AJSBNWAHEDVQJT-UHFFFAOYSA-N

| C=24 | H=28 | N=2 | O=2

| smiles = COc2ccccc2CC(=O)c(c4c1cccc4)cn1CC3CCCCN3C

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Cannabipiperidiethanone (CPE or 1-(N-methylpiperidin-2-ylmethyl)-3-(2-methoxyphenylacetyl)indole) is a synthetic cannabinoid that has been found to be an ingredient of "herbal smoking blends" sold in Japan.

The drug's binding affinity was measured at the CB₁ and CB₂ receptors and it was found to have an IC₅₀ of 591 nM at CB₁ and 968 nM at CB₂, making it 2.3 times and 9.4 times weaker than JWH-250 at these two targets respectively.{{cite journal |vauthors=Uchiyama N, Kikura-Hanajiri R, Goda Y |title=Identification of a novel cannabimimetic phenylacetylindole, cannabipiperidiethanone, as a designer drug in a herbal product and its affinity for cannabinoid CB₁ and CB₂ receptors |journal=Chemical & Pharmaceutical Bulletin |volume=59 |issue=9 |pages=1203–5 |year=2011 |pmid=21881274 |doi= 10.1248/cpb.59.1203|doi-access=free }}

In the United States, CB₁ receptor agonists of the 3-phenylacetylindole class such as cannabipiperidiethanone are Schedule I Controlled Substances.{{UnitedStatesCode2|21|812|Schedules of controlled substances}}