:Chlorophyllin

Chlorophyllin is the active ingredient in a number of internally taken preparations{{medcn|date=May 2019}} intended to reduce odors associated with incontinence, colostomies, and similar procedures, as well as body odor in general. Also in recent years it has been used as a home remedy to treat acne and skin conditions such as pimples or blackheads, thanks to its antimicrobial effect. It is also available as a topical preparation, purportedly useful for both treatment and odor control of wounds, injuries, radiation burns, and other skin conditions.{{cite web | title=Chlorophyllin Uses, Side Effects & Warnings |website=Drugs.com |access-date=2020-03-29 |quote=Chlorophyllin has been used in alternative medicine as an aid to reduce the odor of urine or feces (bowel movements). |url=https://www.drugs.com/mtm/chlorophyllin.html}} The origins of these unsubstantiated medical claims were findings from research by F. Howard Westcott in the 1940s that it was an odor blocker. The commercial value of this attribute in advertising led to many companies creating brands containing the compound in 1950–1953 in particular. It was used as a marketing tool to promote toothpaste, sanitary towels, soap and other products. However, it was soon determined that the hype surrounding chlorophyll or chlorophyllin was not warranted and the underlying research may even have been a hoax. As a result, brands rapidly discontinued its use. In the 2020s, it again became the subject of unsubstantiated medical claims, as social media influencers promoted its use in the form of "chlorophyll water", for example.{{cite journal |doi=10.1108/jhrm-11-2021-0057 |doi-access=free |title=All that glistens is not (Green) gold: Historicising the contemporary chlorophyll fad through a multimodal analysis of Swedish marketing, 1950–1953 |date=2022 |last1=O'Hagan |first1=Lauren Alex |journal=Journal of Historical Research in Marketing |volume=14 |issue=3 |pages=374–398 }}

Chlorophyllin has been used as a biocompatible photoblocker for generating green colored hydrogels with complex inner structures.{{cite journal | doi = 10.1088/2057-1976/aad667 | title = Light-based 3D printing of hydrogels with high-resolution channels | journal = Biomedical Physics & Engineering Express | volume = 5 | issue = 2 | pages = 025035 | year = 2019 | last1 = Benjamin | first1 = Aaron D. | last2 = Abbasi | first2 = Reha | last3 = Owens | first3 = Madison | last4 = Olsen | first4 = Robert J. | last5 = Walsh | first5 = Danica J. | last6 = Lefevre | first6 = Thomas B. | last7 = Wilking | first7 = James N. | url = https://scholarworks.montana.edu/xmlui/handle/1/15266 | doi-access = free }}

Chlorophyllin is water-soluble. In vitro, it binds to some environmental mutagens such as the polycyclic aromatic hydrocarbons benzo[a]pyrene{{cite journal | vauthors=Keshava C, Divi RL, Einem TL, Richardson DL, Leonard SL, Keshava N, Poirier MC, Weston A | title=Chlorophyllin significantly reduces benzo[a]pyrene-DNA adduct formation and alters cytochrome P450 1A1 and 1B1 expression and EROD activity in normal human mammary epithelial cells | journal=Environmental and Molecular Mutagenesis | volume=50 | issue=2 | year=2009 | pages=134–144 | pmid=19152381 | pmc=2637934 | doi=10.1002/em.20449| bibcode=2009EnvMM..50..134K }} and dibenzo[a,i]pyrene.{{cite journal | vauthors=Castro DJ, Löhr CV, Fischer KA, Waters KM, Webb-Robertson BJ, Dashwood RH, Bailey GS, Williams DE | title= Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesi| journal=Carcinogenesis | volume=30 | issue=2 | year=2009 | pages=315–320 | url= | pmid=19073876 | doi=10.1093/carcin/bgn280 | pmc=2722150}} Chlorophyllin also binds to acridine orange.{{cite journal | vauthors=Osowski A, Pietrzak M, Wieczorek Z, Wieczorek J | title=Natural compounds in the human diet and their ability to bind mutagens prevents DNA-mutagen intercalation | journal=Journal of Toxicology and Environmental Health, Part A | volume=73 | issue=17–18 | year=2010 | pages=1141–1149 | pmid=20706936 | doi=10.1080/15287394.2010.491044| bibcode=2010JTEHA..73.1141O | s2cid=11060470 }}

Chlorophyllin has been validated to exhibit ameliorative effects against food additive induced genotoxicity (elevating the expression of DNA repair proteins p53 and PARP) and mitochondrial dysfunction and may be used as a therapeutic tool for the management of diseases like diabetes and cancer.{{Cite journal|last1=Asmita|first1=Samadder|last2=Sudatta|first2=Dey|last3=Priyanka|first3=Sow|last4=Ruchira|first4=Das|last5=Sisir|first5=Nandi|last6=Jayeeta|first6=Das|last7=Banani|first7=Bhattacharjee|last8=Arnob|first8=Chakrovorty|last9=Maharaj|first9=Biswas|last10=Pradeepta|first10=Guptaroy|date=2021-10-31|title=Phyto-chlorophyllin Prevents Food Additive Induced Genotoxicity and Mitochondrial Dysfunction via Cytochrome c Mediated Pathway in Mice Model|url=https://www.eurekaselect.com/189618/article|journal=Combinatorial Chemistry & High Throughput Screening|language=en|volume=24|issue=10|pages=1618–1627|doi=10.2174/1386207323666201230093510|pmid=33380297 |s2cid=229929638 |url-access=subscription}}{{Cite journal|last1=Das|first1=Jayeeta|last2=Samadder|first2=Asmita|last3=Mondal|first3=Jesmin|last4=Abraham|first4=Suresh K.|last5=Khuda-Bukhsh|first5=Anisur Rahman|date=2016-09-01|title=Nano-encapsulated chlorophyllin significantly delays progression of lung cancer both in in vitro and in vivo models through activation of mitochondrial signaling cascades and drug-DNA interaction|url=https://www.sciencedirect.com/science/article/pii/S1382668916301843|journal=Environmental Toxicology and Pharmacology|language=en|volume=46|pages=147–157|doi=10.1016/j.etap.2016.07.006|pmid=27458703 |bibcode=2016EnvTP..46..147D |issn=1382-6689|url-access=subscription}} It has shown to modulate several protein functions including the expression of cytokine proteins NFkβ and IFNγ.{{Cite journal |first1=Asmita |last1=Samadder |first2=Swatilekha |last2=Das |first3=Bakul |last3=Pal |first4=Sweta |last4=Das |first5=Anindita |last5=Mandal |first6=Priyanka |last6=Biswas |first7=Sujoy |last7=Ghosh |first8=Shamim Hossain |last8=Mandal |first9=Priyanka |last9=Sow |first10=Ruchira |last10=Das |first11=Souvik |last11=Biswas |first12=Ashis Kumar |last12=Panigrahi |date=November 24, 2021|title=First report on chlorophyllin to protect mammalian and fish muscle cells from pesticide toxicity via activation of p53 and PARP|journal=Aquaculture and Fisheries|volume=6|issue=4 |pages=393–399|doi=10.1016/j.aaf.2020.07.008|bibcode=2021AqFis...6..393S |s2cid=225189893 |doi-access=free |bibcode-access=free |s2cid-access=free }}

{{Reflist}}

• "[http://lpi.oregonstate.edu/infocenter/phytochemicals/chlorophylls/ Chlorophyll and Chlorophyllin]", Linus Pauling Institute, Oregon State University
• [http://www.cnn.com/video/us/2002/02/27/jm.body.mint.cnn.med.html "A deodorant for every odor" 2002 video from CNN] {{Webarchive|url=https://web.archive.org/web/20070311014241/http://www.cnn.com/video/us/2002/02/27/jm.body.mint.cnn.med.html |date=2007-03-11 }}
• [http://www.food-info.net/uk/e/e141.htm "E141: Copper complexes of chlorophyll", Food-Info.net]

Category:Dietary supplements

Category:Food additives

Category:Copper complexes

Category:Tetrapyrroles

Category:E-number additives