:Chromonychia

Chromonychia is an abnormality in color of the substance or surface of the nail plate or subungual tissues.Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. {{ISBN|0-07-138076-0}}.{{rp|658}}

Chromonychia can be induced by antineoplastic drugs with few distinct forms, the most frequently seen is melanonychia.{{cite journal |vauthors=Unamuno P, Fernández-López E, Santos C |title=Leukonychia due to cytostatic agents |journal=Clin. Exp. Dermatol. |volume=17 |issue=4 |pages=273–4 |date=July 1992 |pmid=1451320 |doi= 10.1111/j.1365-2230.1992.tb02166.x}} Although a few cytostatics may cause these changes, the drugs most commonly involved are adriamycin, cyclophosphamide and vincristine, or in polychemotherapy{{cite journal |vauthors=Chapman S, Cohen PR |title=Transverse leukonychia in patients receiving cancer chemotherapy |journal=South. Med. J. |volume=90 |issue=4 |pages=395–8 |date=April 1997 |pmid=9114829 |doi= 10.1097/00007611-199704000-00006}}{{cite journal|last=Dasanu|first=Constantin A|date=October 31, 2006|url=http://dermatology.cdlib.org/126/case_reports/nail/dasanu.html|title=Distinct patterns of chromonychia, Beau's lines, and melanoderma seen with vincristine, adriamycin, dexamethasone therapy for multiple myeloma |journal=Dermatology Online Journal|volume=12|issue=6|pages=10|pmid=17083890|last2=Vaillant|first2=JG|last3=Alexandrescu|first3=DT}}

Also chromonychia is associated with AIDS. A significant association (p<0.05) was found between chromonychia and CD4 counts of below 200 per cubic millimeter.{{cite journal |vauthors=Monsel G, Ly F, Canestri A, Diousse P, Ndiaye B, Caumes E |title=[Prevalence of skin disorders in HIV patients in Senegal and relationship to degree of immunosuppression] |language=fr |journal=Ann Dermatol Venereol |volume=135 |issue=3 |pages=187–93 |date=March 2008 |pmid=18374849 |doi=10.1016/j.annder.2007.11.022 }}