:Codeine 3-O-demethylase

{{Short description|Enzyme}}

{{redirect|CODM|the Olympics committee of Macau (Comité Olímpico e Desportivo de Macau, China)|Sports and Olympic Committee of Macau, China|the mobile game|Call of Duty: Mobile}}

{{Infobox enzyme

| Name = Codeine 3-O-demethylase

| EC_number = 1.14.11.32

| CAS_number =

| GO_code =

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Codeine 3-O-demethylase ({{EC number|1.14.11.32}}, codeine O-demethylase, CODM) is an enzyme with systematic name codeine,2-oxoglutarate:oxygen oxidoreductase (3-O-demethylating).{{cite journal | vauthors = Hagel JM, Facchini PJ | title = Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy | journal = Nature Chemical Biology | volume = 6 | issue = 4 | pages = 273–5 | date = April 2010 | pmid = 20228795 | doi = 10.1038/nchembio.317 }} This enzyme catalyses the following chemical reaction

: codeine + 2-oxoglutarate + O₂ $\backslash rightleftharpoons$ morphine + formaldehyde + succinate + CO₂

Codeine 3-O-demethylase contains Fe²⁺.