:Demethylrebeccamycin-D-glucose O-methyltransferase

{{Infobox enzyme

| Name = Demethylrebeccamycin-D-glucose O-methyltransferase

| EC_number = 2.1.1.164

| CAS_number =

| GO_code =

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Demethylrebeccamycin-D-glucose O-methyltransferase ({{EC number|2.1.1.164}}, RebM) is an enzyme with systematic name S-adenosyl-L-methionine:demethylrebeccamycin-D-glucose O-methyltransferase.{{cite journal | vauthors = Zhang C, Albermann C, Fu X, Peters NR, Chisholm JD, Zhang G, Gilbert EJ, Wang PG, Van Vranken DL, Thorson JS | title = RebG- and RebM-catalyzed indolocarbazole diversification | journal = ChemBioChem | volume = 7 | issue = 5 | pages = 795–804 | date = May 2006 | pmid = 16575939 | doi = 10.1002/cbic.200500504 | s2cid = 25017820 }}{{cite journal | vauthors = Singh S, McCoy JG, Zhang C, Bingman CA, Phillips GN, Thorson JS | title = Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebM | journal = The Journal of Biological Chemistry | volume = 283 | issue = 33 | pages = 22628–36 | date = August 2008 | pmid = 18502766 | pmc = 2504894 | doi = 10.1074/jbc.M800503200 | doi-access = free }} This enzyme catalyses the following chemical reaction

: 4'-demethylrebeccamycin + S-adenosyl-L-methionine $\backslash rightleftharpoons$ rebeccamycin + S-adenosyl-L-homocysteine

Demethylrebeccamycin-D-glucose O-methyltransferase catalyses the last step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the Actinobacterium Lechevalieria aerocolonigenes.