:Derrubone
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| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 400628942
| ImageFile = Derrubone.svg
| IUPACName = 5,7-Dihydroxy-6-(3-methylbut-2-en-1-yl)-3′,4′-[methylenebis(oxy)]isoflavone
| SystematicName = 3-(2H-1,3-Benzodioxol-5-yl)-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-1-benzopyran-4-one
| OtherNames = 5,7-Dihydroxy-3',4'-methylenedioxy-6-prenylisoflavone
|Section1={{Chembox Identifiers
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| CASNo_Ref = {{cascite|changed|??}}
| CASNo =22044-58-2
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = EVN8G9T8C6
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| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 412010
| PubChem = 5810067
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 4709237
| SMILES = CC(=CCC1=C(C=C2C(=C1O)C(=O)C(=CO2)C3=CC4=C(C=C3)OCO4)O)C
| InChI = 1/C21H18O6/c1-11(2)3-5-13-15(22)8-18-19(20(13)23)21(24)14(9-25-18)12-4-6-16-17(7-12)27-10-26-16/h3-4,6-9,22-23H,5,10H2,1-2H3
| InChIKey = FTBGFGQPUMCUSC-UHFFFAOYAI
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C21H18O6/c1-11(2)3-5-13-15(22)8-18-19(20(13)23)21(24)14(9-25-18)12-4-6-16-17(7-12)27-10-26-16/h3-4,6-9,22-23H,5,10H2,1-2H3
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = FTBGFGQPUMCUSC-UHFFFAOYSA-N
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|Section2={{Chembox Properties
| C=21 | H=18 | O=6
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|Section3={{Chembox Structure
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|Section4={{Chembox Thermochemistry
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|Section5={{Chembox Pharmacology
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|Section6={{Chembox Explosive
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|Section7={{Chembox Hazards
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|Section8={{Chembox Related
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Derrubone is a prenylated isoflavone, a type of flavonoid. It was originally isolated from the Indian tree Derris robusta.{{cite journal |vauthors=East AJ, Ollis WD, Wheeler RE |title=Natural occurrence of 3-aryl-4-hydroxycoumarins. Part I. Phytochemical examination of Derris robusta(roxb.) benth. |journal=J. Chem. Soc. C |volume=3 |pages=365–74 |year=1969 |issue=3 |doi=10.1039/J39690000365 |url=http://www.rsc.org/publishing/journals/J3/article.asp?doi=J39690000365|url-access=subscription }} Recent research indicates that it acts as an inhibitor of Hsp90 to its function as a chaperone protein.{{cite journal |vauthors=Hadden MK, Galam L, Gestwicki JE, Matts RL, Blagg BS |title=Derrubone, an inhibitor of the Hsp90 protein folding machinery |journal=J. Nat. Prod. |volume=70 |issue=12 |pages=2014–8 |date=December 2007 |pmid=18020309 |doi=10.1021/np070190s }}
References
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{{isoflavone}}
{{Aromatic-stub}}