:Diacylglycerol diphosphate phosphatase

{{Infobox enzyme

| Name = Diacylglycerol diphosphate phosphatase

| EC_number = 3.1.3.81

| CAS_number =

| GO_code =

| image =

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Diacylglycerol diphosphate phosphatase ({{EC number|3.1.3.81}}, DGPP phosphatase, DGPP phosphohydrolase, DPP1, DPPL1, DPPL2, PAP2, pyrophosphate phosphatase) is an enzyme with systematic name 1,2-diacyl-sn-glycerol 3-phosphate phosphohydrolase.{{cite journal | vauthors = Dillon DA, Wu WI, Riedel B, Wissing JB, Dowhan W, Carman GM | title = The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity | journal = The Journal of Biological Chemistry | volume = 271 | issue = 48 | pages = 30548–53 | date = November 1996 | pmid = 8940025 | doi = 10.1074/jbc.271.48.30548 | doi-access = free }}{{cite journal | vauthors = Dillon DA, Chen X, Zeimetz GM, Wu WI, Waggoner DW, Dewald J, Brindley DN, Carman GM | title = Mammalian Mg2+-independent phosphatidate phosphatase (PAP2) displays diacylglycerol pyrophosphate phosphatase activity | journal = The Journal of Biological Chemistry | volume = 272 | issue = 16 | pages = 10361–6 | date = April 1997 | pmid = 9099673 | doi = 10.1074/jbc.272.16.10361 | doi-access = free}}{{cite journal | vauthors = Wu WI, Liu Y, Riedel B, Wissing JB, Fischl AS, Carman GM | title = Purification and characterization of diacylglycerol pyrophosphate phosphatase from Saccharomyces cerevisiae | journal = The Journal of Biological Chemistry | volume = 271 | issue = 4 | pages = 1868–76 | date = January 1996 | pmid = 8567632 | doi = 10.1074/jbc.271.4.1868 | doi-access = free | url = https://digitalcommons.uri.edu/cgi/viewcontent.cgi?article=1001&context=chs_past_depts_facpubs | url-access = subscription }}{{cite journal | vauthors = Oshiro J, Han GS, Carman GM | title = Diacylglycerol pyrophosphate phosphatase in Saccharomyces cerevisiae | journal = Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | volume = 1635 | issue = 1 | pages = 1–9 | date = November 2003 | pmid = 14642771 | doi = 10.1016/j.bbalip.2003.10.002 }}{{cite journal | vauthors = Carman GM | title = Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli | journal = Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | volume = 1348 | issue = 1–2 | pages = 45–55 | date = September 1997 | pmid = 9370315 | doi = 10.1016/s0005-2760(97)00095-7 }}{{cite journal | vauthors = Han GS, Johnston CN, Chen X, Athenstaedt K, Daum G, Carman GM | title = Regulation of the Saccharomyces cerevisiae DPP1-encoded diacylglycerol pyrophosphate phosphatase by zinc | journal = The Journal of Biological Chemistry | volume = 276 | issue = 13 | pages = 10126–33 | date = March 2001 | pmid = 11139591 | doi = 10.1074/jbc.m011421200 | doi-access = free }} This enzyme catalyses the following chemical reaction

: 1,2-diacyl-sn-glycerol 3-diphosphate + H₂O $\backslash rightleftharpoons$ 1,2-diacyl-sn-glycerol 3-phosphate + phosphate

The phosphatase activity of this enzyme is Mg²⁺-independent.