:Dihydroorotate dehydrogenase (fumarate)

{{Infobox enzyme

| Name = Dihydroorotate dehydrogenase (fumarate)

| EC_number = 1.3.98.1

| CAS_number = 2603876

| GO_code =

| image =

| width =

| caption =

}}

Dihydroorotate dehydrogenase (fumarate) ({{EC number|1.3.98.1}}, dihydroorotate oxidase, pyr4 (gene)) is an enzyme with systematic name (S)-dihydroorotate:fumarate oxidoreductase.{{cite journal | vauthors = Björnberg O, Rowland P, Larsen S, Jensen KF | title = Active site of dihydroorotate dehydrogenase A from Lactococcus lactis investigated by chemical modification and mutagenesis | journal = Biochemistry | volume = 36 | issue = 51 | pages = 16197–205 | date = December 1997 | pmid = 9405053 | doi = 10.1021/bi971628y }}{{cite journal | vauthors = Rowland P, Björnberg O, Nielsen FS, Jensen KF, Larsen S | title = The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function | journal = Protein Science | volume = 7 | issue = 6 | pages = 1269–79 | date = June 1998 | pmid = 9655329 | pmc = 2144028 | doi = 10.1002/pro.5560070601 }}{{cite journal | vauthors = Nørager S, Arent S, Björnberg O, Ottosen M, Lo Leggio L, Jensen KF, Larsen S | title = Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function | journal = The Journal of Biological Chemistry | volume = 278 | issue = 31 | pages = 28812–22 | date = August 2003 | pmid = 12732650 | doi = 10.1074/jbc.M303767200 | doi-access = free }}{{cite journal | vauthors = Zameitat E, Pierik AJ, Zocher K, Löffler M | title = Dihydroorotate dehydrogenase from Saccharomyces cerevisiae: spectroscopic investigations with the recombinant enzyme throw light on catalytic properties and metabolism of fumarate analogues | journal = FEMS Yeast Research | volume = 7 | issue = 6 | pages = 897–904 | date = September 2007 | pmid = 17617217 | doi = 10.1111/j.1567-1364.2007.00275.x | doi-access = free }}{{cite journal | vauthors = Inaoka DK, Sakamoto K, Shimizu H, Shiba T, Kurisu G, Nara T, Aoki T, Kita K, Harada S | title = Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction | journal = Biochemistry | volume = 47 | issue = 41 | pages = 10881–91 | date = October 2008 | pmid = 18808149 | doi = 10.1021/bi800413r }}{{cite journal | vauthors = Cheleski J, Wiggers HJ, Citadini AP, da Costa Filho AJ, Nonato MC, Montanari CA | title = Kinetic mechanism and catalysis of Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry | journal = Analytical Biochemistry | volume = 399 | issue = 1 | pages = 13–22 | date = April 2010 | pmid = 19932077 | doi = 10.1016/j.ab.2009.11.018 }} This enzyme catalyses the following chemical reaction

: (S)-dihydroorotate + fumarate $\backslash rightleftharpoons$ orotate + succinate

This enzyme contains FMN.