:Dimaprit

{{chembox

| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 360226931

| ImageFile = Dimaprit.svg

| ImageSize = 222

| PIN = 3-(Dimethylamino)propyl carbamimidothioate

| OtherNames = 3-dimethylaminopropyl sulfanylmethanimidamide

| Section1 = {{Chembox Identifiers

| CASNo_Ref = {{cascite|correct|??}}

| CASNo = 65119-89-3

| PubChem = 3077

| ChEMBL_Ref = {{ebicite|changed|EBI}}

| ChEMBL = 12344

| IUPHAR_ligand = 1248

| UNII_Ref = {{fdacite|changed|FDA}}

| UNII = ZZQ699148P

| KEGG_Ref = {{keggcite|changed|kegg}}

| KEGG = C17930

| SMILES = CN(C)CCCSC(=N)N

| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}

| ChemSpiderID = 2968

| InChI = 1/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8)

| InChIKey = OLHQOJYVQUNWPL-UHFFFAOYAQ

| StdInChI_Ref = {{stdinchicite|changed|chemspider}}

| StdInChI = 1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8)

| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}

| StdInChIKey = OLHQOJYVQUNWPL-UHFFFAOYSA-N

}}

| Section2 = {{Chembox Properties

| Formula = C6H15N3S

| MolarMass = 161.2684 g/mol

| Appearance =

| Density =

| MeltingPt =

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| Section3 = {{Chembox Hazards

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| FlashPt =

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Dimaprit is a histamine analog working as a selective H2 histamine receptor agonist.{{cite book|editor1-last=Kartzung|editor1-first=Betram G.|editor2-last=Trevor|editor2-first=Anthony J.|title=Basic and Clinical Pharmacology|date=2014|publisher=McGraw-Hill Education|location=New York|isbn=978-0071825054|page=364|edition=13th}}{{cite journal|last1=Kohno|first1=S|last2=Ogawa|first2=K|last3=Nabe|first3=T|last4=Yamamura|first4=H|last5=Ohata|first5=K|title=Dimaprit, a Histamine H2-agonist, Inhibits Anaphylactic Histamine Release from Mast Cells and the Decreased Release is Restored by Thioperamide (H3-antagonist), but not by Cimetidine (H2-antagonist)|journal=Japanese Journal of Pharmacology|date=May 1993|volume=62|issue=1|pages=75–9|pmid=7688057|doi=10.1254/jjp.62.75|doi-access=free}}{{cite journal|last1=Nakamura|first1=T|last2=Ueno|first2=Y|last3=Goda|first3=Y|last4=Nakamura|first4=A|last5=Shinjo|first5=K|last6=Nagahisa|first6=A|title=Efficacy of a Selective Histamine H2 Receptor Agonist, Dimaprit, in Experimental Models of Endotoxin Shock and Hepatitis in Mice|journal=European Journal of Pharmacology|date=March 1997|volume=322|issue=1|pages=83–89|doi=10.1016/S0014-2999(96)00987-9|pmid=9088875}}

References