:Endothelin-converting enzyme 1

{{Infobox enzyme

| Name = Endothelin-converting enzyme 1

| EC_number = 3.4.24.71

| CAS_number = 138238-81-0

| GO_code =

| image =

| width =

| caption =

}}

Endothelin-converting enzyme 1 ({{EC number|3.4.24.71}}, endothelin-converting enzyme, ECE-1) is an enzyme.{{cite journal | vauthors = Takahashi M, Matsushita Y, Iijima Y, Tanzawa K | title = Purification and characterization of endothelin-converting enzyme from rat lung | journal = The Journal of Biological Chemistry | volume = 268 | issue = 28 | pages = 21394–8 | date = October 1993 | doi = 10.1016/S0021-9258(19)36936-4 | pmid = 8407980 | doi-access = free }}{{cite journal | vauthors = Shimada K, Takahashi M, Tanzawa K | title = Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells | journal = The Journal of Biological Chemistry | volume = 269 | issue = 28 | pages = 18275–8 | date = July 1994 | doi = 10.1016/S0021-9258(17)32298-6 | pmid = 8034569 | doi-access = free }}{{cite journal | vauthors = Xu D, Emoto N, Giaid A, Slaughter C, Kaw S, deWit D, Yanagisawa M | title = ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1 | journal = Cell | volume = 78 | issue = 3 | pages = 473–85 | date = August 1994 | pmid = 8062389 | doi = 10.1016/0092-8674(94)90425-1 | s2cid = 7872049 }} This enzyme catalyses the following chemical reaction

: Hydrolysis of the -Trp²¹-Val- bond in big endothelin to form endothelin 1

This metalloendopeptidase belongs to the peptidase family M13.