:Gary Siuzdak

{{Short description|American chemist}}

{{Infobox scientist

| name = Gary Siuzdak

| image = SizudakDC7.jpg

| birth_date = December 29, 1961

| fields = Analytical Chemistry, Metabolomics

}}

Gary Siuzdak is an American chemist best known for his work in the field of metabolomics,{{Cite journal|last1=Guijas|first1=Carlos|last2=Montenegro-Burke|first2=J. Rafael|last3=Warth|first3=Benedikt|last4=Spilker|first4=Mary E.|last5=Siuzdak|first5=Gary|date=April 2018|title=Metabolomics activity screening for identifying metabolites that modulate phenotype|url= |journal=Nature Biotechnology|volume=36|issue=4|pages=316–320|doi=10.1038/nbt.4101|pmid=29621222 |issn=1546-1696|pmc=5937131}}{{Cite journal|last1=Johnson|first1=Caroline H.|last2=Ivanisevic|first2=Julijana|last3=Siuzdak|first3=Gary|date=July 2016|title=Metabolomics: beyond biomarkers and towards mechanisms|url= |journal=Nature Reviews Molecular Cell Biology|volume=17|issue=7|pages=451–459|doi=10.1038/nrm.2016.25|pmid=26979502 |issn=1471-0080|pmc=5729912}} activity metabolomics{{Cite journal|last1=Rinschen|first1=Markus M.|last2=Ivanisevic|first2=Julijana|last3=Giera|first3=Martin|last4=Siuzdak|first4=Gary|date=June 2019|title=Identification of bioactive metabolites using activity metabolomics|url= |journal=Nature Reviews Molecular Cell Biology|volume=20|issue=6|pages=353–367|doi=10.1038/s41580-019-0108-4|pmid=30814649 |issn=1471-0080|pmc=6613555}}{{Cite journal|last1=Yanes|first1=Oscar|last2=Clark|first2=Julie|last3=Wong|first3=Diana M.|last4=Patti|first4=Gary J.|last5=Sánchez-Ruiz|first5=Antonio|last6=Benton|first6=H. Paul|last7=Trauger|first7=Sunia A.|last8=Desponts|first8=Caroline|last9=Ding|first9=Sheng|last10=Siuzdak|first10=Gary|date=June 2010|title=Metabolic oxidation regulates embryonic stem cell differentiation|url= |journal=Nature Chemical Biology|volume=6|issue=6|pages=411–417|doi=10.1038/nchembio.364|pmid=20436487 |issn=1552-4469|pmc=2873061}}{{Cite journal|last1=Lerner|first1=R. A.|last2=Siuzdak|first2=G.|last3=Prospero-Garcia|first3=O.|last4=Henriksen|first4=S. J.|last5=Boger|first5=D. L.|last6=Cravatt|first6=B. F.|date=1994-09-27|title=Cerebrodiene: a brain lipid isolated from sleep-deprived cats|journal=Proceedings of the National Academy of Sciences|volume=91|issue=20|pages=9505–9508|pmc=44841|doi=10.1073/pnas.91.20.9505|issn=0027-8424|pmid=7937797|bibcode=1994PNAS...91.9505L |doi-access=free }}{{Cite journal|last1=Montenegro-Burke|first1=J. Rafael|last2=Kok|first2=Bernard P.|last3=Guijas|first3=Carlos|last4=Domingo-Almenara|first4=Xavier|last5=Moon|first5=Clara|last6=Galmozzi|first6=Andrea|last7=Kitamura|first7=Seiya|last8=Eckmann|first8=Lars|last9=Saez|first9=Enrique|last10=Siuzdak|first10=Gary E.|last11=Wolan|first11=Dennis W.|date=2021-09-28|title=Metabolomics activity screening of T cell–induced colitis reveals anti-inflammatory metabolites|journal=Science Signaling|volume=14|issue=702|pages=eabf6584|doi=10.1126/scisignal.abf6584|pmid=34582249 |pmc=8757460 }} (a termed coined in 2019{{Cite journal|last1=Rinschen|first1=Markus M.|last2=Ivanisevic|first2=Julijana|last3=Giera|first3=Martin|last4=Siuzdak|first4=Gary|date=June 2019|title=Identification of bioactive metabolites using activity metabolomics|journal=Nature Reviews Molecular Cell Biology|volume=20|issue=6|pages=353–367|doi=10.1038/s41580-019-0108-4|pmid=30814649 |pmc=6613555 |issn=1471-0080}}), and mass spectrometry.{{Cite journal|last1=Giera|first1=Martin|last2=Yanes|first2=Oscar|last3=Siuzdak|first3=Gary|date=2022-01-04|title=Metabolite discovery: Biochemistry's scientific driver|journal=Cell Metabolism|volume=34|issue=1|pages=21–34|doi=10.1016/j.cmet.2021.11.005|pmid=34986335 |pmc=10131248 |s2cid=245729571 |issn=1550-4131|doi-access=free}} His lab discovered indole-3-propionic acid as a gut bacteria derived metabolite in 2009.{{Cite journal |last1=Guijas |first1=Carlos |last2=Horton |first2=Lucy E. |last3=Hoang |first3=Linh |last4=Domingo-Almenara |first4=Xavier |last5=Billings |first5=Elizabeth M. |last6=Ware |first6=Brian C. |last7=Sullivan |first7=Brian |last8=Siuzdak |first8=Gary |date=July 2022 |title=Microbial Metabolite 3-Indolepropionic Acid Mediates Immunosuppression |journal=Metabolites |volume=12 |issue=7 |pages=645 |doi=10.3390/metabo12070645 |doi-access=free |pmid=35888769 |pmc=9317520 |issn=2218-1989}}{{Cite journal |last1=Serger |first1=Elisabeth |last2=Luengo-Gutierrez |first2=Lucia |last3=Chadwick |first3=Jessica S. |last4=Kong |first4=Guiping |last5=Zhou |first5=Luming |last6=Crawford |first6=Greg |last7=Danzi |first7=Matt C. |last8=Myridakis |first8=Antonis |last9=Brandis |first9=Alexander |last10=Bello |first10=Adesola Temitope |last11=Müller |first11=Franziska |last12=Sanchez-Vassopoulos |first12=Alexandros |last13=De Virgiliis |first13=Francesco |last14=Liddell |first14=Phoebe |last15=Dumas |first15=Marc Emmanuel |date=July 2022 |title=The gut metabolite indole-3 propionate promotes nerve regeneration and repair |url=https://www.nature.com/articles/s41586-022-04884-x |journal=Nature |volume=607 |issue=7919 |pages=585–592 |doi=10.1038/s41586-022-04884-x |pmid=35732737 |bibcode=2022Natur.607..585S |issn=1476-4687}} He is currently the Professor and Director of The Center for Metabolomics and Mass Spectrometry at Scripps Research in La Jolla, California.{{cite web |title=Faculty Page, Gary Siuzdak |url=https://www.scripps.edu/faculty/siuzdak/ |website=scripps.edu |accessdate=22 May 2019}} Siuzdak has also made contributions to virus analysis, viral structural dynamics,{{Cite journal|last1=Bothner|first1=Brian|last2=Dong|first2=X. Fan|last3=Bibbs|first3=Lisa|last4=Johnson|first4=John E.|last5=Siuzdak|first5=Gary|date=1998-01-09|title=Evidence of Viral Capsid Dynamics Using Limited Proteolysis and Mass Spectrometry|journal=Journal of Biological Chemistry|volume=273|issue=2|pages=673–676|doi=10.1074/jbc.273.2.673|issn=0021-9258|pmid=9422714|doi-access=free}}{{Cite journal|last1=Lewis|first1=J. Kathleen|last2=Bothner|first2=Brian|last3=Smith|first3=Thomas J.|last4=Siuzdak|first4=Gary|date=1998-06-09|title=Antiviral agent blocks breathing of the common cold virus|journal=Proceedings of the National Academy of Sciences|volume=95|issue=12|pages=6774–6778|pmc=22631 |doi=10.1073/pnas.95.12.6774|issn=0027-8424|pmid=9618488|bibcode=1998PNAS...95.6774L |doi-access=free}}{{Cite journal|last1=Bothner|first1=Brian|last2=Schneemann|first2=Anette|last3=Marshall|first3=Dawn|last4=Reddy|first4=Vijay|last5=Johnson|first5=John E.|last6=Siuzdak|first6=Gary|date=February 1999|title=Crystallographically identical virus capsids display different properties in solution|url=https://www.nature.com/articles/nsb0299_114|journal=Nature Structural Biology|volume=6|issue=2|pages=114–116|doi=10.1038/5799|pmid=10048920 |s2cid=1756648 |issn=1545-9985|url-access=subscription}} as well as developing mass spectrometry imaging technology using nanostructured surfaces. The Siuzdak lab is also responsible for creating the research tools eXtensible Computational Mass Spectrometry (XCMS),{{Cite journal|last1=Smith|first1=Colin A.|last2=Want|first2=Elizabeth J.|last3=O'Maille|first3=Grace|last4=Abagyan|first4=Ruben|last5=Siuzdak|first5=Gary|date=2006-02-01|title=XCMS: Processing Mass Spectrometry Data for Metabolite Profiling Using Nonlinear Peak Alignment, Matching, and Identification|url=https://doi.org/10.1021/ac051437y|journal=Analytical Chemistry|volume=78|issue=3|pages=779–787|doi=10.1021/ac051437y|pmid=16448051 |issn=0003-2700|url-access=subscription}}{{Citation |last1=Domingo-Almenara |first1=Xavier |title=Metabolomics Data Processing Using XCMS |date=2020 |url=https://doi.org/10.1007/978-1-0716-0239-3_2 |work=Computational Methods and Data Analysis for Metabolomics |pages=11–24 |editor-last=Li |editor-first=Shuzhao |access-date=2023-07-13 |series=Methods in Molecular Biology |place=New York, NY |publisher=Springer US |doi=10.1007/978-1-0716-0239-3_2 |isbn=978-1-0716-0239-3 |last2=Siuzdak |first2=Gary|volume=2104 |pmid=31953810 |s2cid=210709390 |url-access=subscription }} METLIN,{{Cite journal|last1=Xue|first1=Jingchuan|last2=Guijas|first2=Carlos|last3=Benton|first3=H. Paul|last4=Warth|first4=Benedikt|last5=Siuzdak|first5=Gary|date=2020-08-24|title=METLIN MS 2 molecular standards database: a broad chemical and biological resource|journal=Nature Methods|volume=17 |issue=10 |pages=953–954|doi=10.1038/s41592-020-0942-5|pmid=32839599 |pmc=8802982 |issn=1548-7105}} METLIN Neutral Loss{{Cite journal|last1=Aisporna|first1=Aries|last2=Benton|first2=H. Paul|last3=Galano|first3=Jean Marie|last4=Giera|first4=Martin|last5=Siuzdak|first5=Gary|date=2021-04-04|title=METLIN Neutral Loss Database Enhances Similarity Analysis|url=https://www.biorxiv.org/content/10.1101/2021.04.02.438066v2|pages=2021.04.02.438066|doi=10.1101/2021.04.02.438066|s2cid=233175525 |doi-access=free}} and Q-MRM.{{Cite journal|last1=Xue|first1=Jingchuan|last2=Derks|first2=Rico J. E.|last3=Webb|first3=Bill|last4=Billings|first4=Elizabeth M.|last5=Aisporna|first5=Aries|last6=Giera|first6=Martin|last7=Siuzdak|first7=Gary|date=2021-08-10|title=Single Quadrupole Multiple Fragment Ion Monitoring Quantitative Mass Spectrometry|url=https://doi.org/10.1021/acs.analchem.1c01246|journal=Analytical Chemistry|volume=93|issue=31|pages=10879–10889|doi=10.1021/acs.analchem.1c01246|pmid=34313111 |pmc=8762722 |hdl=1887/3243130 |issn=0003-2700}}{{Cite journal|last1=Xue|first1=Jingchuan|last2=Derks|first2=Rico J. E.|last3=Hoang|first3=Linh|last4=Giera|first4=Martin|last5=Siuzdak|first5=Gary|date=2021-10-11|title=Proteomics with Enhanced In-Source Fragmentation/Annotation: Applying XCMS-EISA Informatics and Q-MRM High-Sensitivity Quantification|journal=Journal of the American Society for Mass Spectrometry|volume=32 |issue=11 |pages=2644–2654 |doi=10.1021/jasms.1c00188|pmid=34633184 |s2cid=238581609 |issn=1044-0305|pmc=10245389}} As of January 2021,{{Cite journal|last1=Majumder|first1=Erica L.-W.|last2=Billings|first2=Elizabeth M.|last3=Benton|first3=H. Paul|last4=Martin|first4=Richard L.|last5=Palermo|first5=Amelia|last6=Guijas|first6=Carlos|last7=Rinschen|first7=Markus M.|last8=Domingo-Almenara|first8=Xavier|last9=Montenegro-Burke|first9=J. Rafael|last10=Tagtow|first10=Bradley A.|last11=Plumb|first11=Robert S.|date=2021-01-22|title=Cognitive analysis of metabolomics data for systems biology|journal=Nature Protocols|volume=16 |issue=3 |pages=1376–1418|doi=10.1038/s41596-020-00455-4|pmid=33483720 |osti=1774918 |s2cid=231687415 |issn=1750-2799|pmc=10357461}} the XCMS/METLIN platform has over 50,000 registered users.

Siuzdak studied chemistry (B.S.) and applied mathematics (B.A.) at Rhode Island College. He then went to Dartmouth College for his graduate work where he built his first mass spectrometer{{Cite journal|last1=Siuzdak|first1=Gary.|last2=BelBruno|first2=Joseph J.|date=May 1990|title=Laser multiphoton dissociation/ionization of butylamines: competitive processes in radical cations|url=https://pubs.acs.org/doi/pdf/10.1021/j100374a038|journal=The Journal of Physical Chemistry|volume=94|issue=11|pages=4559–4565|doi=10.1021/j100374a038|issn=0022-3654|url-access=subscription}} to perform multi-photon ionization mass spectrometry experiments and occasionally competed in powerlifting.{{cite news |last1=Scandura |first1=Mike |title=Weightlifting the right way good for Siuzdak |publisher=The Evening Times (Pawtucket, R.I.) |date=30 Dec 1987}} At Dartmouth he received his Ph.D. in Physical Chemistry (March 29, 1990) and on April 1, 1990, started at Scripps Research. In 2017 Siuzdak received an honorary doctorate (with Emmanuelle Charpentier) from Umeå University{{Cite web|title=Biochemist and metabolomics researcher take honorary roles at Umeå University|url=https://www.umu.se/en/news/biochemist-and-metabolomics-researcher-take-honorary-roles-at-umea-university_5814196/|access-date=2020-10-21|website=www.umu.se}} for his work in metabolomics. Siuzdak has hundreds of [https://scholar.google.com/citations?user=3BpMXA8AAAAJ&hl=en papers] and has authored two books: Mass Spectrometry for Biotechnology (1996) and The Expanding Role of Mass Spectrometry in Biotechnology (2003) as well as The Expanding Role of Mass Spectrometry in Biotechnology 2nd Ed. (2006).{{cite web |title=Interview with Dr. Gary Siuzdak |url=http://www.metabonews.ca/Sep2012/MetaboNews_Sep2012.htm#MetaboInterviews |website=MetaboNews, Issue 13 - September 2012 |accessdate=22 May 2019}}