:Glucose-6-phosphate dehydrogenase (coenzyme-F420)

{{Infobox enzyme

| Name = Glucose-6-phosphate dehydrogenase (coenzyme-F420)

| EC_number = 1.1.98.2

| CAS_number =

| GO_code =

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Glucose-6-phosphate dehydrogenase (coenzyme-F420) ({{EC number|1.1.98.2}}, coenzyme F420-dependent glucose-6-phosphate dehydrogenase, F420-dependent glucose-6-phosphate dehydrogenase, FGD1, Rv0407, F420-dependent glucose-6-phosphate dehydrogenase 1) is an enzyme with systematic name D-glucose-6-phosphate:F420 1-oxidoreductase.{{cite journal | vauthors = Purwantini E, Daniels L | title = Purification of a novel coenzyme F420-dependent glucose-6-phosphate dehydrogenase from Mycobacterium smegmatis | journal = Journal of Bacteriology | volume = 178 | issue = 10 | pages = 2861–6 | date = May 1996 | pmid = 8631674 | pmc = 178021 }}{{cite journal | vauthors = Bashiri G, Squire CJ, Baker EN, Moreland NJ | title = Expression, purification and crystallization of native and selenomethionine labeled Mycobacterium tuberculosis FGD1 (Rv0407) using a Mycobacterium smegmatis expression system | journal = Protein Expression and Purification | volume = 54 | issue = 1 | pages = 38–44 | date = July 2007 | pmid = 17376702 | doi = 10.1016/j.pep.2007.01.014 }}{{cite journal | vauthors = Purwantini E, Gillis TP, Daniels L | title = Presence of F420-dependent glucose-6-phosphate dehydrogenase in Mycobacterium and Nocardia species, but absence from Streptomyces and Corynebacterium species and methanogenic Archaea | journal = FEMS Microbiology Letters | volume = 146 | issue = 1 | pages = 129–34 | date = January 1997 | pmid = 8997717 | doi = 10.1111/j.1574-6968.1997.tb10182.x | doi-access = free }} This enzyme catalyses the following chemical reaction

: D-glucose 6-phosphate + oxidized coenzyme F420 $\backslash rightleftharpoons$ 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420

Thus enzyme is specific for D-glucose 6-phosphate.