:Glutamyl endopeptidase II

{{Infobox enzyme

| Name = Glutamyl endopeptidase II

| EC_number = 3.4.21.82

| CAS_number = 137010-42-5

| GO_code =

| image =

| width =

| caption =

}}

Glutamyl endopeptidase II ({{EC number|3.4.21.82}}, GluSGP) is an enzyme.{{cite journal | vauthors = Yoshida N, Tsuruyama S, Nagata K, Hirayama K, Noda K, Makisumi S | title = Purification and characterization of an acidic amino acid specific endopeptidase of Streptomyces griseus obtained from a commercial preparation (Pronase) | journal = Journal of Biochemistry | volume = 104 | issue = 3 | pages = 451–6 | date = September 1988 | pmid = 3149277 }}{{cite journal | vauthors = Komiyama T, Bigler TL, Yoshida N, Noda K, Laskowski M | title = Replacement of P1 Leu18 by Glu18 in the reactive site of turkey ovomucoid third domain converts it into a strong inhibitor of Glu-specific Streptomyces griseus proteinase (GluSGP) | journal = The Journal of Biological Chemistry | volume = 266 | issue = 17 | pages = 10727–30 | date = June 1991 | pmid = 1674942 }}{{cite journal | vauthors = Nagata K, Yoshida N, Ogata F, Araki M, Noda K | title = Subsite mapping of an acidic amino acid-specific endopeptidase from Streptomyces griseus, GluSGP, and protease V8 | journal = Journal of Biochemistry | volume = 110 | issue = 6 | pages = 859–62 | date = December 1991 | pmid = 1794975 }}{{cite journal | vauthors = Svendsen I, Jensen MR, Breddam K | title = The primary structure of the glutamic acid-specific protease of Streptomyces griseus | journal = FEBS Letters | volume = 292 | issue = 1-2 | pages = 165–7 | date = November 1991 | pmid = 1959600 | doi = 10.1016/0014-5793(91)80859-2 | doi-access = free }}{{cite journal | vauthors = Breddam K, Meldal M | title = Substrate preferences of glutamic-acid-specific endopeptidases assessed by synthetic peptide substrates based on intramolecular fluorescence quenching | journal = European Journal of Biochemistry | volume = 206 | issue = 1 | pages = 103–7 | date = May 1992 | pmid = 1587264 | doi = 10.1111/j.1432-1033.1992.tb16906.x | doi-access = free }} This enzyme catalyses the following chemical reaction

: Preferential cleavage: -Glu- >> -Asp- . Preference for Pro or Leu at P2 and Phe at P3. Cleavage of -Glu-Asp- and -Glu-Pro- bonds is slow

This enzyme is isolated from Streptomyces griseus.