:Hypodermin C

{{Infobox enzyme

| Name = Hypodermin C

| EC_number = 3.4.21.49

| CAS_number = 122191-36-0

| GO_code =

| image =

| width =

| caption =

}}

Hypodermin C ({{EC number|3.4.21.49}}, Hypoderma collagenase) is an enzyme.{{cite journal | vauthors = Lecroisey A, Boulard C, Keil B | title = Chemical and enzymatic characterization of the collagenase from the insect Hypoderma lineatum | journal = European Journal of Biochemistry | volume = 101 | issue = 2 | pages = 385–93 | date = November 1979 | pmid = 230030 | doi = 10.1111/j.1432-1033.1979.tb19730.x | doi-access = free }}{{cite journal | vauthors = Lecroisey A, Keil B | title = Specificity of the collagenase from the insect Hypoderma lineatum | journal = European Journal of Biochemistry | volume = 152 | issue = 1 | pages = 123–30 | date = October 1985 | pmid = 2995028 | doi = 10.1111/j.1432-1033.1985.tb09171.x | doi-access = free }}{{cite journal | vauthors = Lecroisey A, Gilles AM, De Wolf A, Keil B | title = Complete amino acid sequence of the collagenase from the insect Hypoderma lineatum | journal = The Journal of Biological Chemistry | volume = 262 | issue = 16 | pages = 7546–51 | date = June 1987 | pmid = 3034899 }} This enzyme catalyses the following chemical reaction

: Hydrolysis of proteins including native collagen at -Ala bond leaving an N-terminal (75%) and a C-terminal (25%) fragment

This enzyme is isolated from the larva of a warble fly, Hypoderma lineatum.