:Inositol-1,3,4-trisphosphate 5/6-kinase

{{Infobox enzyme

| Name = inositol-1,3,4-trisphosphate 5/6-kinase

| EC_number = 2.7.1.159

| CAS_number = 288307-53-9

| GO_code =

| image =

| width =

| caption =

}}

inositol-1,3,4-trisphosphate 5/6-kinase ({{EC number|2.7.1.159}}, Ins(1,3,4)P3 5/6-kinase, inositol trisphosphate 5/6-kinase) is an enzyme with systematic name ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase.{{cite journal | vauthors = Wilson MP, Majerus PW | title = Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme | journal = The Journal of Biological Chemistry | volume = 271 | issue = 20 | pages = 11904–10 | date = May 1996 | pmid = 8662638 | doi = 10.1074/jbc.271.20.11904 | doi-access = free }}{{cite journal | vauthors = Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW | title = The pathway for the production of inositol hexakisphosphate in human cells | journal = The Journal of Biological Chemistry | volume = 280 | issue = 3 | pages = 1911–20 | date = January 2005 | pmid = 15531582 | doi = 10.1074/jbc.M411528200 | doi-access = free }}{{cite journal | vauthors = Miller GJ, Wilson MP, Majerus PW, Hurley JH | title = Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase | journal = Molecular Cell | volume = 18 | issue = 2 | pages = 201–12 | date = April 2005 | pmid = 15837423 | doi = 10.1016/j.molcel.2005.03.016 | doi-access = free }} This enzyme catalyses the following chemical reaction

: (1) ATP + 1D-myo-inositol 1,3,4-trisphosphate $\backslash rightleftharpoons$ ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate

: (2) ATP + 1D-myo-inositol 1,3,4-trisphosphate $\backslash rightleftharpoons$ ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate

In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6).