:JK-05

{{Short description|Chemical compound}}

{{about|the antiviral drug|the light aircraft|Ekolot JK-05L Junior}}

{{Drugbox

| IUPAC_name =

| image =

| tradename =

| legal_US = Investigational New Drug

| legal_status =

| bioavailability =

| metabolism =

| elimination_half-life =

| excretion =

| CAS_number = 1911641-25-2

| PubChem =

| ChemSpiderID =

| C= | H= | N= | O=

| molecular_weight =

| smiles =

| StdInChI =

| StdInChIKey =

}}

JK-05 is a broad-spectrum antiviral drug developed by the Chinese company Sihuan Pharmaceutical along with the Chinese Academy of Military Medical Sciences. It is reported to act as an inhibitor of the viral enzyme RNA polymerase, which is essential for viral replication. In tests on mice, JK-05 was claimed to show efficacy against a range of RNA viruses, including influenza, Ebola virus, and yellow fever, as well as several arenaviruses and bunyaviruses. The chemical structure of JK-05 has not been disclosed as of October 2014, but it is claimed to be a small molecule drug with a comparatively simple structure, which should be readily amenable to synthesis scale-up for mass production if testing is successful. The drug is, however, admitted to be similar to the Japanese anti-influenza drug favipiravir, developed by Fujifilm Holdings Corp, which has been used effectively to treat patients with Ebola.{{cite news | first = Adam | last = Jourdan | name-list-style = vanc | url=https://www.reuters.com/article/us-health-ebola-china-idUSKCN0I30M920141014 | title=China military-linked firm eyes quick approval of drug to cure Ebola| newspaper=Reuters| date=2014-10-14}} In addition, WHO committee members mentioned that the drug is a copy product of favipiravir, because patents of favipiravir were already registered in 2006 in China.{{cite web |url=http://headlines.yahoo.co.jp/hl?a=20141121-00000005-jct-bus_all |title=Suspected Pakuri in "Ebola special drug" developed in Japan WHO points out that the same ingredient is manufactured in China | language = ja | work = J-CAST News |access-date=2014-11-21 |url-status=dead |archive-url=https://web.archive.org/web/20141129170049/http://headlines.yahoo.co.jp/hl?a=20141121-00000005-jct-bus_all |archive-date=2014-11-29 }} The drug has been given preliminary approval by the Chinese authorities to be available for Chinese health workers involved in combating the 2014 West African Ebola outbreak, or if Ebola were to spread into mainland China.{{cite web | url = http://www.scmp.com/news/china/article/1582834/ebola-virus-approved-mainland-emergency-use-only | title = Ebola virus drug approved on mainland for emergency use only. | first = Zhuang | last = Pinghui | name-list-style = vanc | work = South China Morning Post | date = 1 September 2014 }}{{cite web | url = http://www.bioworld.com/content/china-approves-ebola-drug-emergency-use-0 | title = China approves Ebola drug for emergency use. | first = Kristine | last = Yang | name-list-style = vanc | work = Bioworld.com }}{{cite web | url = http://french.cri.cn/621/2014/10/18/502s406121.htm | title = La Chine envoie des médicaments contre Ebola en Afrique | language = fr | work = CRI Online | date = 18 October 2014 | access-date = 19 October 2014 | archive-date = 3 March 2016 | archive-url = https://web.archive.org/web/20160303231208/http://french.cri.cn/621/2014/10/18/502s406121.htm | url-status = dead }}{{cite web | url = http://www.guosen.com.hk/upload/20141016/201410161413422546726.pdf | title = Sihuan Pharma Company Update | date = 15 October 2014 | access-date = 19 October 2014 | archive-date = 24 January 2022 | archive-url = https://web.archive.org/web/20220124005048/http://www.guosen.com.hk/upload/20141016/201410161413422546726.pdf | url-status = dead }}{{cite web | url = http://www.dw.de/beijing-develops-ebola-drug/a-18013324 | title = Beijing develops Ebola drug. | first = Frank | last = Sieren | name-list-style = vanc | work = Deutsche Welle | date = 23 October 2014 }} Several other Chinese developed antiviral drugs with anti-Ebola activity have also been disclosed,{{cite journal | vauthors = Wu W, Liu S | title = [Research progress of prevention and treatment of Ebola virus infection] | language = zh | journal = Nan Fang Yi Ke da Xue Xue Bao = Journal of Southern Medical University | volume = 34 | issue = 10 | pages = 1519–22 | date = October 2014 | pmid = 25345954 }} but have not progressed so far through development as JK-05.{{citation needed|date=May 2017}}