:L-peptidase

{{Infobox enzyme

| Name = L-peptidase

| EC_number = 3.4.22.46

| CAS_number =

| GO_code =

| image =

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| caption =

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L-peptidase ({{EC number|3.4.22.46}}) is an enzyme.{{cite journal | vauthors = Piccone ME, Zellner M, Kumosinski TF, Mason PW, Grubman MJ | title = Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus | journal = Journal of Virology | volume = 69 | issue = 8 | pages = 4950–6 | date = August 1995 | pmid = 7609064 | pmc = 189310 }}{{cite journal | vauthors = Guarné A, Hampoelz B, Glaser W, Carpena X, Tormo J, Fita I, Skern T | title = Structural and biochemical features distinguish the foot-and-mouth disease virus leader proteinase from other papain-like enzymes | journal = Journal of Molecular Biology | volume = 302 | issue = 5 | pages = 1227–40 | date = October 2000 | pmid = 11183785 | doi = 10.1006/jmbi.2000.4115 | hdl = 10261/111148 | hdl-access = free }} This enzyme catalyses the following chemical reaction

: Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-Gly bond. Subsequently, it cleaves host cell initiation factor eIF-4G at bonds -Gly-Arg- and -Lys-Arg-

This enzyme is coded bz foot-and-mouth disease virus.