:Lethal acantholytic epidermolysis bullosa
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| image = Autosomal recessive - en.svg
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| caption = This condition is inherited in an autosomal recessive manner.
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| field = Dermatology
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Lethal acantholytic epidermolysis bullosa is a fatal genetic skin disorder caused by mutations in DSPSee OMIM entry for complete details{{cite web |title=Epidermolysis bullosa, lethal acantholytic {{!}} Genetic and Rare Diseases Information Center (GARD) – an NCATS Program |url=https://rarediseases.info.nih.gov/diseases/9910/epidermolysis-bullosa-lethal-acantholytic |website=rarediseases.info.nih.gov |accessdate=23 February 2019}}{{Cite journal|last1=Bardhan|first1=Ajoy|last2=Bruckner-Tuderman|first2=Leena|last3=Chapple|first3=Iain L. C.|last4=Fine|first4=Jo-David|last5=Harper|first5=Natasha|last6=Has|first6=Cristina|last7=Magin|first7=Thomas M.|last8=Marinkovich|first8=M. Peter|last9=Marshall|first9=John F.|last10=McGrath|first10=John A.|last11=Mellerio|first11=Jemima E.|date=2020-09-24|title=Epidermolysis bullosa|url=https://www.nature.com/articles/s41572-020-0210-0|journal=Nature Reviews Disease Primers|language=en|volume=6|issue=1|page=78|doi=10.1038/s41572-020-0210-0|pmid=32973163|s2cid=221861310|issn=2056-676X|url-access=subscription}}
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| ICD10 = Q81.0
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| OMIM = 609638
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| MeSH = C535493
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| Orphanet = 158687
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{{Genodermatoses-stub|}}