:Lupeol synthase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = Lupeol synthase

| EC_number = 5.4.99.41

| CAS_number =

| GO_code =

| image =

| width =

| caption =

}}

Lupeol synthase ({{EnzExplorer|5.4.99.41}}, LUPI, BPW, RcLUS) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, lupeol-forming).{{cite journal | vauthors = Herrera JB, Bartel B, Wilson WK, Matsuda SP | title = Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene | journal = Phytochemistry | volume = 49 | issue = 7 | pages = 1905–11 | date = December 1998 | pmid = 9883589 | doi = 10.1016/s0031-9422(98)00366-5 }}{{cite journal | vauthors = Shibuya M, Zhang H, Endo A, Shishikura K, Kushiro T, Ebizuka Y | title = Two branches of the lupeol synthase gene in the molecular evolution of plant oxidosqualene cyclases | journal = European Journal of Biochemistry | volume = 266 | issue = 1 | pages = 302–7 | date = November 1999 | pmid = 10542078 | doi = 10.1046/j.1432-1327.1999.00875.x | doi-access = free }}{{cite journal | vauthors = Segura MJ, Meyer MM, Matsuda SP | title = Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol | journal = Organic Letters | volume = 2 | issue = 15 | pages = 2257–9 | date = July 2000 | pmid = 10930257 | doi = 10.1021/ol006016b }}{{cite journal | vauthors = Zhang H, Shibuya M, Yokota S, Ebizuka Y | title = Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants | journal = Biological & Pharmaceutical Bulletin | volume = 26 | issue = 5 | pages = 642–50 | date = May 2003 | pmid = 12736505 | doi = 10.1248/bpb.26.642 | doi-access = free }}{{cite journal | vauthors = Hayashi H, Huang P, Takada S, Obinata M, Inoue K, Shibuya M, Ebizuka Y | title = Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra | journal = Biological & Pharmaceutical Bulletin | volume = 27 | issue = 7 | pages = 1086–92 | date = July 2004 | pmid = 15256745 | doi = 10.1248/bpb.27.1086 | doi-access = free }}{{cite journal | vauthors = Guhling O, Hobl B, Yeats T, Jetter R | title = Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis | journal = Archives of Biochemistry and Biophysics | volume = 448 | issue = 1–2 | pages = 60–72 | date = April 2006 | pmid = 16445885 | doi = 10.1016/j.abb.2005.12.013 }}{{cite journal | vauthors = Basyuni M, Oku H, Tsujimoto E, Kinjo K, Baba S, Takara K | title = Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae | journal = The FEBS Journal | volume = 274 | issue = 19 | pages = 5028–42 | date = October 2007 | pmid = 17803686 | doi = 10.1111/j.1742-4658.2007.06025.x | doi-access = }} This enzyme catalyses the following chemical reaction

: (3S)-2,3-epoxy-2,3-dihydrosqualene $\backslash rightleftharpoons$ lupeol

Also forms some beta-amyrin.