:Malonyl CoA reductase (malonate semialdehyde-forming)

{{Infobox enzyme

| Name = Malonyl CoA reductase (malonate semialdehyde-forming)

| EC_number = 1.2.1.75

| CAS_number =

| GO_code =

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Malonyl CoA reductase (malonate semialdehyde-forming) ({{EC number|1.2.1.75}}, NADP-dependent malonyl CoA reductase, malonyl CoA reductase (NADP)) is an enzyme with systematic name malonate semialdehyde:NADP⁺ oxidoreductase (malonate semialdehyde-forming).{{cite journal | vauthors = Strauss G, Fuchs G | title = Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle | journal = European Journal of Biochemistry | volume = 215 | issue = 3 | pages = 633–43 | date = August 1993 | pmid = 8354269 | doi = 10.1111/j.1432-1033.1993.tb18074.x | doi-access = free }}{{cite journal | vauthors = Berg IA, Kockelkorn D, Buckel W, Fuchs G | title = A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea | journal = Science | volume = 318 | issue = 5857 | pages = 1782–6 | date = December 2007 | pmid = 18079405 | doi = 10.1126/science.1149976 }}{{cite journal | vauthors = Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hügler M, Fuchs G | title = Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp | journal = Journal of Bacteriology | volume = 188 | issue = 24 | pages = 8551–9 | date = December 2006 | pmid = 17041055 | pmc = 1698253 | doi = 10.1128/JB.00987-06 | url = http://oceanrep.geomar.de/6268/1/J.%20Bacteriol.-2006-Alber-8551-9.pdf }}{{cite journal | vauthors = Hügler M, Menendez C, Schägger H, Fuchs G | title = Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation | journal = Journal of Bacteriology | volume = 184 | issue = 9 | pages = 2404–10 | date = May 2002 | pmid = 11948153 | pmc = 134993 | doi = 10.1128/jb.184.9.2404-2410.2002 }} This enzyme catalyse the following chemical reaction

: malonate semialdehyde + CoA + NADP⁺ $\backslash rightleftharpoons$ malonyl-CoA + NADPH + H⁺

Requires Mg²⁺. Catalyses the reduction of malonyl-CoA to malonate semialdehyde.