:Melanizing agents
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Melanizing agents are drugs that increase sensitivity to solar radiation and promote re-pigmentation of de-pigmented areas of skin. Furocoumarins stimulate melanocytes and induce their proliferation on activation by light. Melanizing agents sensitize the skin to sunlight. As a result, erythema, inflammation and pigmentation occurs.
Drugs
Psoralen is a natural drug obtained from the fruit of Psoralea corylifolia.{{cite web|title=Definition of Psoralen|url=http://medical-dictionary.thefreedictionary.com/psoralen|publisher=The Free Medical Dictionary|accessdate=8 August 2012}} Methoxsalen{{cite web|title=Definition of Methoxsalen|url=http://medical-dictionary.thefreedictionary.com/methoxsalen|publisher=The Free Medical Dictionary|accessdate=8 August 2012}} and Trioxsalen{{cite web|title=Definition of Trioxsalen|url=http://medical-dictionary.thefreedictionary.com/trioxsalen|accessdate=8 August 2012}} are synthetic psoralens. These drugs can be used either topically or orally.
=Topical therapy=
The drug solution is painted on the vitiliginous lesion and exposed to sunlight for around one minute. It is then occluded by a sunscreen ointment. The treatment should be undertaken for many weeks to obtain observable results. Longer exposure to sunlight might cause blistering of skin, so the therapy should be undertaken in the direct supervision of a physician.{{cite book|last=Tripathi|first=J.D|title=Melanizing agents|date=December 2008 |publisher=Jaypee Publications|isbn=978-81-8448-085-6}}
=Oral therapy=
It is done in alternate days. After 2 hours of taking the oral dose of 20 mg/day of a psoralen, skin is exposed to sunlight. Eyes, ears and other normally pigmented areas should be protected while spending time in the sun.{{cite web|last=Parrish|first=John|title=Photochemotherapy of Vitilago|url=http://archderm.jamanetwork.com/article.aspx?articleid=536465|work=Archives of Dermatology|publisher=JAMA Network}}
See also
References
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