:Methanesulfonate monooxygenase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = Methanesulfonate monooxygenase

| EC_number = 1.14.13.111

| CAS_number =

| GO_code =

| image =

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Methanesulfonate monooxygenase ({{EC number|1.14.13.111}}, mesylate monooxygenase, mesylate,reduced-FMN:oxygen oxidoreductase, MsmABCD, methanesulfonic acid monooxygenase, MSA monooxygenase, MSAMO) is an enzyme with systematic name methanesulfonate,NADH:oxygen oxidoreductase.{{cite journal | vauthors = de Marco P, Moradas-Ferreira P, Higgins TP, McDonald I, Kenna EM, Murrell JC | title = Molecular analysis of a novel methanesulfonic acid monooxygenase from the methylotroph Methylosulfonomonas methylovora | journal = Journal of Bacteriology | volume = 181 | issue = 7 | pages = 2244–51 | date = April 1999 | pmid = 10094704 | pmc = 93639 }}{{cite journal | vauthors = Higgins TP, Davey M, Trickett J, Kelly DP, Murrell JC | title = Metabolism of methanesulfonic acid involves a multicomponent monooxygenase enzyme | journal = Microbiology | volume = 142 ( Pt 2) | pages = 251–60 | date = February 1996 | pmid = 8932698 | doi = 10.1099/13500872-142-2-251 | doi-access = free }} This enzyme catalyses the following chemical reaction

: methanesulfonate + NADH + H⁺ + O₂ $\backslash rightleftharpoons$ formaldehyde + NAD⁺ + sulfite + H₂O

Methanesulfonate monooxygenase is a flavoprotein.