:Methylphosphonate synthase

{{short description|Class of enzymes}}

{{Infobox enzyme

| Name = Methylphosphonate synthase

| EC_number = 1.13.11.73

| CAS_number =

| GO_code =

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Methylphosphonate synthase ({{EC number|1.13.11.73}}, mpnS (gene)) is an enzyme with systematic name 2-hydroxyethylphosphonate:O₂ 1,2-oxidoreductase (methylphosphonate forming).{{cite journal | vauthors = Metcalf WW, Griffin BM, Cicchillo RM, Gao J, Janga SC, Cooke HA, Circello BT, Evans BS, Martens-Habbena W, Stahl DA, van der Donk WA | title = Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean | journal = Science | volume = 337 | issue = 6098 | pages = 1104–7 | date = August 2012 | pmid = 22936780 | pmc = 3466329 | doi = 10.1126/science.1219875 }} This enzyme catalyses the following chemical reaction

: 2-hydroxyethylphosphonate + O₂ $\backslash rightleftharpoons$ methylphosphonate + HCO³⁻

Methylphosphonate synthase is isolated from the marine archaeon Nitrosopumilus maritimus.