:Nicotine blue oxidoreductase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = Nicotine blue oxidoreductase

| EC_number = 1.1.1.328

| CAS_number =

| GO_code =

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Nicotine blue oxidoreductase ({{EC number|1.1.1.328}}, nboR (gene)) is an enzyme with systematic name 3,3'-bipyridine-2,2',5,5',6,6'-hexol:NADP⁺ 11-oxidoreductase.{{cite journal | vauthors = Mihasan M, Chiribau CB, Friedrich T, Artenie V, Brandsch R | title = An NAD(P)H-nicotine blue oxidoreductase is part of the nicotine regulon and may protect Arthrobacter nicotinovorans from oxidative stress during nicotine catabolism | journal = Applied and Environmental Microbiology | volume = 73 | issue = 8 | pages = 2479–85 | date = April 2007 | pmid = 17293530 | pmc = 1855579 | doi = 10.1128/AEM.02668-06 }} This enzyme catalyses the following chemical reaction

: 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(P)⁺ $\backslash rightleftharpoons$ (E)-2,2',5,5'-tetrahydroxy-6H,6'H-[3,3'-bipyridinylidene]-6,6'-dione + NAD(P)H + H⁺

This enzyme is extracted from bacterium Arthrobacter nicotinovorans.