:Palmoplantar hyperhidrosis

Palmoplantar hyperhidrosis is a frequent disorder when excessive amounts of sweat are inappropriately secreted by the eccrine glands in the palms and soles.{{cite journal | last1=Thomas | first1=Isabelle | last2=Brown | first2=Justin | last3=Vafaie | first3=Janet | last4=Schwartz | first4=Robert A. | title=Palmoplantar Hyperhidrosis: A Therapeutic Challenge | journal=American Family Physician | volume=69 | issue=5 | date=2004-03-01 | pages=1117–1121 |url=https://www.aafp.org/pubs/afp/issues/2004/0301/p1117.html | access-date=2024-05-07}}

There is little knowledge about the pathogenesis of focal hyperhidrosis. Focal hyperhidrosis may indicate a complicated autonomic nervous system malfunction involving both parasympathetic and sympathetic pathways.{{cite journal | last=Haider | first=A. | title=Focal hyperhidrosis: diagnosis and management | journal=Canadian Medical Association Journal | volume=172 | issue=1 | date=2005-01-04 | issn=0820-3946 | pmid=15632408 | pmc=543948 | doi=10.1503/cmaj.1040708 | pages=69–75}} Given that 30% to 50% of patients have a family history of hyperhidrosis, there may be a genetic susceptibility.{{cite journal | last=Stolman | first=Lewis P. | title=Treatment of Hyperhidrosis | journal=Dermatologic Clinics | publisher=Elsevier BV | volume=16 | issue=4 | year=1998 | issn=0733-8635 | doi=10.1016/s0733-8635(05)70062-0 | pages=863–869| pmid=9891696 }}

Because the excessive sweating is easily noticeable, palmoplantar hyperhidrosis is a clinical diagnosis.

For palmoplantar hyperhidrosis, 20% aluminum chloride hexahydrate in absolute anhydrous ethyl alcohol (Drysol) is the most effective topical treatment. Other topical treatments such as potassium permanganate, tannic acid (2 to 5 percent solutions), resorcinol, boric acid, formaldehyde, methenamine, and glutaraldehyde have yielded less than desirable results.

Iontophoresis is a well-known treatment for hyperhidrosis that involves applying a direct electrical current to the skin.{{cite journal | last1=Bouman | first1=H. D. | last2=Lentzer | first2=E. M. G. | title=The treatment of hyperhidrosis of hands and feet with constant current | journal=American Journal of Physical Medicine | volume=31 | issue=3 | date=1952 | issn=0002-9491 | pmid=14943812 | pages=158–169}} Iontophoresis has been combined with a variety of substances, such as tap water, salt water, and anticholinergic medications.{{cite journal | last1=Sato | first1=K. | last2=Timm | first2=D. E. | last3=Sato | first3=F. | last4=Templeton | first4=E. A. | last5=Meletiou | first5=D. S. | last6=Toyomoto | first6=T. | last7=Soos | first7=G. | last8=Sato | first8=S. K. | title=Generation and transit pathway of H+ is critical for inhibition of palmar sweating by iontophoresis in water | journal=Journal of Applied Physiology | publisher=American Physiological Society | volume=75 | issue=5 | date=1993-11-01 | issn=8750-7587 | doi=10.1152/jappl.1993.75.5.2258 | pages=2258–2264}}

Botulinum toxin type A (Botox) injections are safe, efficient, and frequently enhance the quality of life for those who suffer from hyperhidrosis.{{cite journal | last1=Tan | first1=Stephen R. | last2=Solish | first2=Nowell | title=Long-Term Efficacy and Quality of Life in the Treatment of Focal Hyperhidrosis with Botulinum Toxin A | journal=Dermatologic Surgery | publisher=Ovid Technologies (Wolters Kluwer Health) | volume=28 | issue=6 | year=2002 | issn=1076-0512 | doi=10.1046/j.1524-4725.2002.01159.x | pages=495–499}} The toxin damages the sweat glands' post-ganglionic sympathetic innervation and prevents acetylcholine from being released at the neuromuscular junction.{{cite journal | last1=Shelley | first1=W.B. | last2=Talanin | first2=N.Y. | last3=Shelley | first3=E.D. | title=Botulinum toxin therapy for palmar hyperhidrosis | journal=Journal of the American Academy of Dermatology | publisher=Elsevier BV | volume=38 | issue=2 | year=1998 | issn=0190-9622 | doi=10.1016/s0190-9622(98)70242-7 | pages=227–229| pmid=9486678 }}

• Hyperhidrosis

{{reflist}}

• {{cite journal | last1=Iwase | first1=Satoshi | last2=Ikeda | first2=Takehiko | last3=Kitazawa | first3=Hiroki | last4=Hakusui | first4=Shigetaka | last5=Sugenoya | first5=Junichi | last6=Mano | first6=Tadaaki | title=Altered response in cutaneous sympathetic outflow to mental and thermal stimuli in primary palmoplantar hyperhidrosis | journal=Journal of the Autonomic Nervous System | publisher=Elsevier BV | volume=64 | issue=2–3 | year=1997 | issn=0165-1838 | doi=10.1016/s0165-1838(97)00014-3 | pages=65–73 | ref=none}}
• {{cite journal | last1=Eilertsen | first1=Trond | last2=Kvammen | first2=Bjørn Øivind | last3=Grimstad | first3=Øystein | title=Botulinum Toxin A and B for Palmoplantar Hyperhidrosis | journal=Dermatology and Therapy | volume=14 | issue=3 | date=2024 | issn=2193-8210 | pmid=38424385 | pmc=10965841 | doi=10.1007/s13555-024-01113-3 | pages=805–811 | ref=none}}

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{{Disorders of skin appendages}}

Category:Conditions of the skin appendages