:Paromamine 6'-oxidase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = Paromamine 6'-oxidase

| EC_number = 1.1.3.43

| CAS_number =

| GO_code =

| image =

| width =

| caption =

}}

Paromamine 6'-oxidase ({{EC number|1.1.3.43}}, btrQ (gene), neoG (gene), kanI (gene), tacB (gene)) is an enzyme with systematic name paromamine:oxygen 6'-oxidoreductase.{{cite journal | vauthors = Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB | title = Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin | journal = ChemBioChem | volume = 8 | issue = 3 | pages = 283–8 | date = February 2007 | pmid = 17206729 | doi = 10.1002/cbic.200600371 }}{{cite journal | vauthors = Yu Y, Hou X, Ni X, Xia H | title = Biosynthesis of 3'-deoxy-carbamoylkanamycin C in a Streptomyces tenebrarius mutant strain by tacB gene disruption | journal = The Journal of Antibiotics | volume = 61 | issue = 2 | pages = 63–9 | date = February 2008 | pmid = 18408324 | doi = 10.1038/ja.2008.111 | doi-access = free }}{{cite journal | vauthors = Clausnitzer D, Piepersberg W, Wehmeier UF | title = The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin | journal = Journal of Applied Microbiology | volume = 111 | issue = 3 | pages = 642–51 | date = September 2011 | pmid = 21689223 | doi = 10.1111/j.1365-2672.2011.05082.x | doi-access = free }} This enzyme catalyses the following chemical reaction

: paromamine + O₂ $\backslash rightleftharpoons$ 6'-dehydroparomamine + H₂O₂

This enzymes participates in biosynthesis of several aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin.