:Phosalone

{{chembox

| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 464204750

| ImageFile= Phosalone Structure.svg

| ImageSize=

| ImageFile1=Phosalone-spacefilling-from-AHRLS-2011.png

| ImageSize1=200px

| PIN=S-[(6-Chloro-2-oxo-1,3-benzoxazol-3(2H)-yl)methyl] O,O-diethyl phosphorodithioate

| OtherNames=Zolone

|Section1={{Chembox Identifiers

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 4629

| InChI = 1/C12H15ClNO4PS2/c1-3-16-19(20,17-4-2)21-8-14-10-6-5-9(13)7-11(10)18-12(14)15/h5-7H,3-4,8H2,1-2H3

| InChIKey = IOUNQDKNJZEDEP-UHFFFAOYAA

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChI = 1S/C12H15ClNO4PS2/c1-3-16-19(20,17-4-2)21-8-14-10-6-5-9(13)7-11(10)18-12(14)15/h5-7H,3-4,8H2,1-2H3

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey = IOUNQDKNJZEDEP-UHFFFAOYSA-N

| CASNo_Ref = {{cascite|correct|CAS}}

| CASNo=2310-17-0

| PubChem=4793

| ChEMBL_Ref = {{ebicite|changed|EBI}}

| ChEMBL = 1528531

| KEGG_Ref = {{keggcite|correct|kegg}}

| KEGG = C11028

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 448B85HT8M

| ChEBI_Ref = {{ebicite|correct|EBI}}

| ChEBI = 8121

| SMILES = Clc2ccc1c(OC(=O)N1CSP(=S)(OCC)OCC)c2

}}

|Section2={{Chembox Properties

| C=12 | H=15 | Cl=1 | N=1 | O=4 | P=1 | S=2

| Appearance = Colorless crystalline

| Odor = garlic

| Density = 1.39 g cm−3

| MeltingPtC = 47.5 to 48

| BoilingPt =

| Solubility = 3.05 mg/L

| SolubleOther = many organic solvents

}}

|Section3={{Chembox Hazards

| MainHazards=

| FlashPt=

| AutoignitionPt =

}}

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Phosalone is an organophosphate chemical commonly used as an insecticide and acaricide. It is developed by Rhône-Poulenc in France but EU eliminated it from pesticide registration in December 2006.

The median lethal dose of oral exposure in rat is 85 mg/kg and that of dermal is 390 mg/kg.[http://www.jaish.gr.jp/anzen/gmsds/2310-17-0.html 製品安全データシート(安全衛生情報センター)] {{webarchive|url=https://web.archive.org/web/20141025104610/http://www.jaish.gr.jp/anzen/gmsds/2310-17-0.html |date=2014-10-25 }}。It is a weak acetylcholinesterase inhibitor.{{Cite web |url=http://www.nihs.go.jp/ICSC/icssj-c/icss0797c.html |title=国際化学物質安全性カード |access-date=2012-09-06 |archive-url=https://web.archive.org/web/20121211034027/http://www.nihs.go.jp/ICSC/icssj-c/icss0797c.html |archive-date=2012-12-11 |url-status=dead }} It is taken by not only oral and inhalation but skin and it causes toxic symptoms peculiar to organophosphorus compounds such as miosis, hypersalivation, hyperhidrosis, chest pressure, pulmonary edema and fecal incontinence.{{Cite book

| author=植村振作・河村宏・辻万千子・冨田重行・前田静夫著

| year=2002

| title=農薬毒性の事典 改訂版

| publisher=三省堂

| isbn=978-4385356044

}} It is flammable and decomposes to toxic gases such as phosphorus oxides, sulfur oxides and nitrogen oxides. It is harmful especially to water creatures.

References

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