:Plasmepsin I

{{Infobox enzyme

| Name = Plasmepsin I

| EC_number = 3.4.23.38

| CAS_number = 180189-87-1

| GO_code =

| image =

| width =

| caption =

}}

Plasmepsin I ({{EC number|3.4.23.38}}, aspartic hemoglobinase I, PFAPG, malaria aspartic hemoglobinase) is an enzyme.{{cite journal | vauthors = Goldberg DE, Slater AF, Beavis R, Chait B, Cerami A, Henderson GB | title = Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease | journal = The Journal of Experimental Medicine | volume = 173 | issue = 4 | pages = 961–9 | date = April 1991 | pmid = 2007860 | pmc = 2190804 | doi = 10.1084/jem.173.4.961 }}{{cite journal | vauthors = Francis SE, Gluzman IY, Oksman A, Knickerbocker A, Mueller R, Bryant ML, Sherman DR, Russell DG, Goldberg DE | title = Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase | journal = The EMBO Journal | volume = 13 | issue = 2 | pages = 306–17 | date = January 1994 | pmid = 8313875 | pmc = 394809 | doi = 10.1002/j.1460-2075.1994.tb06263.x }}{{cite journal | vauthors = Gluzman IY, Francis SE, Oksman A, Smith CE, Duffin KL, Goldberg DE | title = Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway | journal = The Journal of Clinical Investigation | volume = 93 | issue = 4 | pages = 1602–8 | date = April 1994 | pmid = 8163662 | pmc = 294190 | doi = 10.1172/JCI117140 }} This enzyme catalyses the following chemical reaction

: Hydrolysis of the -Phe³³-Leu- bond in the alpha-chain of hemoglobin, leading to denaturation of the molecule

This enzyme is present in the malaria organism, Plasmodium.