:Protein–energy malnutrition

{{see also|Prenatal nutrition}}

Protein undernutrition is detrimental at any point in life, but protein undernutrition prenatally has been shown to have significant lifelong effects. Diets that consist of less than 6% protein in utero have been linked with many deficits, including decreased brain weight, increased obesity, and impaired communication within the brain in some animals. Even diets of mild protein undernutrition (7.2%) have been shown to have lasting and significant effects in rats. The following are some studies in which prenatal protein deficiency has been shown to have unfavorable consequences.

• Decreased brain size: Protein deficiency has been shown to affect the size and composition of brains in rhesus monkeys. Monkeys whose mother had eaten a diet with an adequate amount of protein were shown to have no deficit in brain size or composition, even when their body weight amounted to less than one-half of that of the controls, whereas monkeys whose mothers had eaten low-protein diets were shown to have smaller brains regardless of the diet given after birth.{{cite journal |vauthors=Portman OW, Neuringer M, Alexander M |title=Effects of maternal and long-term postnatal protein malnutrition on brain size and composition in rhesus monkeys |journal=The Journal of Nutrition |volume=117 |issue=11 |pages=1844–51 |date=November 1987 |pmid=3681475 |doi= 10.1093/jn/117.11.1844|url=http://jn.nutrition.org/cgi/pmidlookup?view=long&pmid=3681475|doi-access=free }}
• Impaired neocortical long-term potentiation: Mild protein deficiency (in which 7.2% of the diet consists of protein) in rats has been shown to impair entorhinal cortex plasticity (visuospatial memory), noradrenergic function in the neocortex, and neocortical long-term potentiation.{{cite journal |vauthors=Hernández A, Burgos H, Mondaca M, Barra R, Núñez H, Pérez H, Soto-Moyano R, Sierralta W, Fernández V, Olivares R, Valladares L |title=Effect of prenatal protein malnutrition on long-term potentiation and BDNF protein expression in the rat entorhinal cortex after neocortical and hippocampal tetanization |journal=Neural Plasticity |volume=2008 |pages=1–9 |year=2008 |pmid=18604298 |pmc=2442167 |doi=10.1155/2008/646919 |doi-access=free }}
• Altered fat distribution: Protein undernutrition can have varying effects depending on the period of fetal life during which the malnutrition occurred. Although there were not significant differences in the food intake, there were increased amounts of perirenal fat in rats that were protein-deprived during early (gestation days 0–7) and mid (gestation days 8–14) pregnancy, and throughout pregnancy, whereas rats that were protein-deprived only late in gestation (gestation days 15–22) were shown to have increased gonadal fat.{{cite journal|author3-link=Simon Langley-Evans|vauthors=Bellinger L, Sculley DV, Langley-Evans SC |title=Exposure to undernutrition in fetal life determines fat distribution, locomotor activity and food intake in ageing rats |journal=International Journal of Obesity |volume=30 |issue=5 |pages=729–38 |date=May 2006 |pmid=16404403 |pmc=1865484 |doi=10.1038/sj.ijo.0803205 }}
• Increased obesity: Mice exposed to a low-protein diet prenatally weighed 40% less than the control group at birth (intrauterine growth retardation). When fed a high-fat diet after birth, the prenatally undernourished mice were shown to have increased body weight and adiposity (body fat), while those who were adequately nourished prenatally did not show an increase in body weight or adiposity when fed the same high-fat diet after birth.{{cite journal |vauthors=Sutton GM, Centanni AV, Butler AA |title=Protein malnutrition during pregnancy in C57BL/6J mice results in offspring with altered circadian physiology before obesity |journal=Endocrinology |volume=151 |issue=4 |pages=1570–80 |date=April 2010 |pmid=20160133 |pmc=2850243 |doi=10.1210/en.2009-1133 |url=http://endo.endojournals.org/cgi/pmidlookup?view=long&pmid=20160133}}
• Decreased birth weight, and gestation duration: Supplementation of protein and energy can lead to increased duration of gestation and higher birth weight. When fed a supplement containing protein, energy, and micronutrients, pregnant women showed more successful results during birth, including high birth weights, longer gestations, and fewer pre-term births, than women who had consumed a supplement with micronutrients and low energy but no protein (although this finding may be due to the increase of energy in the supplements, not the increase of protein).{{cite journal |vauthors=Rasmussen KM, Habicht JP |title=Maternal supplementation differentially affects the mother and newborn |journal=The Journal of Nutrition |volume=140 |issue=2 |pages=402–6 |date=February 2010 |pmid=20032480 |doi=10.3945/jn.109.114488 |url=http://jn.nutrition.org/cgi/pmidlookup?view=long&pmid=20032480|doi-access= }}
• Increased stress sensitivity: Male offspring of pregnant rats fed low-protein diets have been shown to exhibit blood pressure that is hyperresponsive to stress and salt.{{cite journal |vauthors=Augustyniak RA, Singh K, Zeldes D, Singh M, Rossi NF |title=Maternal protein restriction leads to hyperresponsiveness to stress and salt-sensitive hypertension in male offspring |journal=American Journal of Physiology. Regulatory, Integrative and Comparative Physiology |volume=298 |issue=5 |pages=R1375–82 |date=May 2010 |pmid=20200128 |pmc=2867525 |doi=10.1152/ajpregu.00848.2009 }}
• Decreased sperm quality: A low-protein diet during gestation in rats has been shown to affect the sperm quality of the male offspring in adulthood. The protein deficiency appeared to reduce sertoli cell number, sperm motility, and sperm count.{{cite journal |vauthors=Toledo FC, Perobelli JE, Pedrosa FP, Anselmo-Franci JA, Kempinas WD |title=In utero protein restriction causes growth delay and alters sperm parameters in adult male rats |journal=Reproductive Biology and Endocrinology |volume=9 |pages=94 |year=2011 |pmid=21702915 |pmc=3141647 |doi=10.1186/1477-7827-9-94 |doi-access=free }}
• Altered cardiac energy metabolism: Prenatal nutrition, specifically protein nutrition, may affect the regulation of cardiac energy metabolism through changes in specific genes.{{cite journal |vauthors=Slater-Jefferies JL, Lillycrop KA, Townsend PA, Torrens C, Hoile SP, Hanson MA, Burdge GC |title=Feeding a protein-restricted diet during pregnancy induces altered epigenetic regulation of peroxisomal proliferator-activated receptor-α in the heart of the offspring |journal=Journal of Developmental Origins of Health and Disease |volume=2 |issue=4 |pages=250–255 |date=August 2011 |pmid=22003431 |pmc=3191520 |doi=10.1017/S2040174410000425 }}
• Increased passive stiffness: Intrauterine undernutrition was shown to increase passive stiffness in skeletal muscles in rats.{{cite journal |vauthors=Toscano AE, Ferraz KM, Castro RM, Canon F |title=Passive stiffness of rat skeletal muscle undernourished during fetal development |journal=Clinics (Sao Paulo) |volume=65 |issue=12 |pages=1363–9 |year=2010 |pmid=21340228 |pmc=3020350 |doi= 10.1590/s1807-59322010001200022}}

From these studies it is possible to conclude that prenatal protein nutrition is vital to the development of the fetus, especially the brain, the susceptibility to diseases in adulthood, and even gene expression. When pregnant females of various species were given low-protein diets, the offspring were shown to have many deficits. These findings highlight the great significance of adequate protein in the prenatal diet.

File:Protein-energy malnutrition world map-Deaths per million persons-WHO2012.svg

Although protein energy malnutrition is more common in low-income countries, children from higher-income countries are also affected, including children from large urban areas in low socioeconomic neighborhoods. This may also occur in children with chronic diseases, and children who are institutionalized or hospitalized for a different diagnosis. Risk factors include a primary diagnosis of intellectual disability, cystic fibrosis, malignancy, cardiovascular disease, end stage renal disease, oncologic disease, genetic disease, neurological disease, multiple diagnoses, or prolonged hospitalization. In these conditions, the challenging nutritional management may get overlooked and underestimated, resulting in an impairment of the chances for recovery and the worsening of the situation.{{cite web|title=Marasmus and Kwashiorkor|publisher=Medscape Reference|date=May 2009|url=http://emedicine.medscape.com/article/984496-overview}}

PEM is fairly common worldwide in both children and adults and accounts for 250,000 deaths annually. In the industrialized world, PEM is predominantly seen in hospitals, is associated with disease, or is often found in the elderly.

A large percentage of children that suffer from PEM also have other co-morbid conditions. The most common co-morbidities are diarrhea (72.2% of a sample of 66 subjects) and malaria (43.3%). However, a variety of other conditions have been observed with PEM, including sepsis, severe anaemia, bronchopneumonia, HIV, tuberculosis, scabies, chronic suppurative otitis media, rickets, and keratomalacia. These co-morbidities, according to Agozie Ubesie and other paediatricians, tax already malnourished children and may prolong hospital stays initially for PEM and may increase the likelihood of death.{{Cite journal|last1=Ubesie|first1=Agozie C.|last2=Ibeziako|first2=Ngozi S.|last3=Ndiokwelu|first3=Chika I.|last4=Uzoka|first4=Chinyeaka M.|last5=Nwafor|first5=Chinelo A.|date=2012-01-01|title=Under-five Protein Energy Malnutrition Admitted at the University of In Nigeria Teaching Hospital, Enugu: a 10 year retrospective review|journal=Nutrition Journal|volume=11|pages=43|doi=10.1186/1475-2891-11-43|issn=1475-2891|pmc=3487930|pmid=22704641 |doi-access=free }}

The general explanation of increased infectious comorbidity in malnourished people is that (1) the immune system is what prevents such diseases from being more widespread in healthy, well-nourished people and (2) malnutrition stresses and diminishes immune function. In other words, malnutrition tends to cause (mild or moderate) immunodeficiency, eroding the barriers that normally keep infectious diseases at bay. For example, this reversal is well established regarding the variable natural history of tuberculosis in the pre–TB drug era. Epidemiologically, there are also associations between malnutrition and other health risks via the common underlying factor of poverty. For example, condoms can reduce spread of HIV, but impoverished people often may not have money to buy condoms or a nearby place to buy them. Also, once a poor person has any particular infection, they may not have access to optimal treatment of it, which allows it to get worse, present more chances of transmission, and so on. Even when a developing country nominally/officially has national health insurance with universal health care, the poorest quarter of its population may face a de facto reality of poor health care access.

{{Reflist}}

{{refbegin}}

• {{cite journal |pages=172–5 |doi=10.1016/S0272-6386(99)70278-7 |title=Protein–energy malnutrition in dialysis patients |year=1999 |last1=Bistrian |first1=Bruce R. |last2=McCowen |first2=Karen C. |last3=Chan |first3=Samuel |journal=American Journal of Kidney Diseases |volume=33 |pmid=9915286 |issue=1}}
• {{MerckManual|01|002|b||Protein–Energy Undernutrition}}

{{refend}}

{{Medical resources

| DiseasesDB =

| ICD11 = {{ICD11|5B71 }}

| ICD10 = {{ICD10|E|40||e|40}}-{{ICD10|E|44||e|40}}

| ICD9 = {{ICD9|260}}-{{ICD9|263}}

| ICDO =

| OMIM =

| MedlinePlus =

| eMedicineSubj = derm

| eMedicineTopic = 797

| MeshID =D011502

}}

{{Nutritional pathology}}

{{DEFAULTSORT:Protein-energy malnutrition}}