:Reticular pigmented anomaly of the flexures

{{Infobox medical condition (new)

| name = Reticular pigmented anomaly of the flexures

| synonyms = Kitamura reticulate acropigmentation{{cite web |title=Dowling-Degos disease {{!}} Genetic and Rare Diseases Information Center (GARD) – an NCATS Program |url=https://rarediseases.info.nih.gov/diseases/9775/disease |website=rarediseases.info.nih.gov |access-date=23 April 2019}}

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| field = dermatology

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Reticular pigmented anomaly of the flexures (also known as dark dot disease and Dowling–Degos disease) is a fibrous anomaly of the flexures or bending parts of the axillae, neck and inframammary/sternal areas.James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. {{ISBN|0-7216-2921-0}}.{{rp|856}} It is an autosomal-dominant pigmentary disorder that may appear in adolescence or adulthood. This condition is due to mutations in structural/desmosomal proteins found within stratified squamous epithelium.{{cite book |author=Rapini, Ronald P. |author2=Bolognia, Jean L. |author3=Jorizzo, Joseph L. |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis |year=2007 |isbn=978-1-4160-2999-1 }}

Dark dot disease is associated with KRT5.{{cite journal |vauthors=Betz RC, Planko L, Eigelshoven S, etal |title=Loss-of-function mutations in the keratin 5 gene lead to Dowling-Degos disease |journal=Am. J. Hum. Genet. |volume=78 |issue=3 |pages=510–9 |date=March 2006 |pmid=16465624 |pmc=1380294 |doi=10.1086/500850 }}